{"refrec":{"BRefID":348217,"RR":"<b>Fedosov, A.; Zaharias, P.; Puillandre, N.</b> (2021). A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails. <i>Proc. - Royal Soc., Biol. Sci. 288(1954)</i>: 20211017. <a href=\"https://dx.doi.org/10.1098/rspb.2021.1017\" target=\"_blank\">https://dx.doi.org/10.1098/rspb.2021.1017</a>","BEntID":344911,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Proc. - Royal Soc., Biol. Sci. 288(1954)</i>: 20211017. <a href=\"https://dx.doi.org/10.1098/rspb.2021.1017\" target=\"_blank\">https://dx.doi.org/10.1098/rspb.2021.1017</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Fedosov, A.; Zaharias, P.; Puillandre, N.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Fedosov, A.; Zaharias, P.; Puillandre, N.","Englishabstract":"Marine gastropods of the genus <i>Conus</i> are renowned for their remarkable diversity and deadly venoms. While <i>Conus</i> venoms are increasingly well studied for their biomedical applications, we know surprisingly little about venom composition in other lineages of Conidae. We performed comprehensive venom transcriptomic profiling for <i>Conasprella coriolisi</i> and <i>Pygmaeconus traillii</i>, first time for both respective genera. We complemented reference-based transcriptome annotation by a <i>de novo</i> toxin prediction guided by phylogeny, which involved transcriptomic data on two additional ‘divergent’ cone snail lineages, <i>Profundiconus</i>, and <i>Californiconus</i>. We identified toxin clusters (SSCs) shared among all or some of the four analysed genera based on the identity of the signal region—a molecular tag present in toxins. In total, 116 and 98 putative toxins represent 29 and 28 toxin gene superfamilies in <i>Conasprella</i> and <i>Pygmaeconus</i>, respectively; about quarter of these only found by semi-manual annotation of the SSCs. Two rare gene superfamilies, originally identified from fish-hunting cone snails, were detected outside <i>Conus</i> rather unexpectedly, so we further investigated their distribution across Conidae radiation. We demonstrate that both these, in fact, are ubiquitous in Conidae, sometimes with extremely high expression. 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