{"refrec":{"BRefID":34857,"RR":"<b>Torkildsen, L.; Coyne, R.; Samuelsen, O.B.; Magnesen, T.; Bergh, Ø.</b> (2002). Treatment of the early life stages of scallop (<i>Pecten maximus</i>) with antimicrobial agents; searching for an alternative to chloramphenicol. <i>Aquacult. Int. 10(5)</i>: 399-409. <a href=\"https://dx.doi.org/10.1023/A:1023347020675\" target=\"_blank\">https://dx.doi.org/10.1023/A:1023347020675</a>","BEntID":34857,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Aquacult. Int. 10(5)</i>: 399-409. <a href=\"https://dx.doi.org/10.1023/A:1023347020675\" target=\"_blank\">https://dx.doi.org/10.1023/A:1023347020675</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Torkildsen, L.; Coyne, R.; Samuelsen, O.B.; Magnesen, T.; Bergh, Ø.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Torkildsen, L. <i>et al.</i>","Englishabstract":"High mortality rates are often observed in rearing the early stages of the great scallop,<i>Pecten maximus</i>. The addition of antibacterial agents has been necessary to improve larval survival. However, as one antibacterial agent, chloramphenicol, is banned in Norway and Europe the aim of this study is to investigate alternative antibacterial agents. The therapeutic agents investigated in this study were florfenicol, oxytetracycline, oxolinic acid, neomycin and Pyceze. The mean minimum inhibitory concentration (MIC) values were determined for oxytetracycline, oxolinic acid and Pyceze against bacteria isolated from scallop larvae. Two types of treatment regime were investigated on an intermediate scale (20 L). One regime involved continuous exposure of scallop larvae to the therapeutic agent while the other involved a short exposure lasting two hours. All intermediate scale treatments were performed in parallel to large-scale production (800 L) treatment with chloramphenicol. Of the therapeutants investigated, oxolinic acid was the most effective, although only at high concentrations. 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