Document of bibliographic reference 349956

BibliographicReference record

Type

Bibliographic resource

Type of document

Journal article

BibLvlCode

AS

Title

Comparative venomics of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus

Abstract

he venom duct transcriptomes and proteomes of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus were obtained and compared. The most abundant and shared conotoxin precursor superfamilies in both species were M, O1, and O2. Additionally, three new putative conotoxin precursor superfamilies (Virro01-03) with cysteine pattern types VI/VII and XVI were identified. The most expressed conotoxin precursor superfamilies were SF-mi2 and M in V. ebraeus, and Cerm03 and M in V. judaeus. Up to 16 conotoxin precursor superfamilies and hormones were differentially expressed between both species, and clustered into two distinct sets, which could represent adaptations of each species to different diets. Finally, we predicted, with machine learning algorithms, the 3D structure model of selected venom proteins including the differentially expressed Cerm03 and SF-mi2, an insulin type 3, a Gastridium geographus GVIA-like conotoxin, and an ortholog to the Pionoconus magus ω-conotoxin MVIIA (Ziconotide).

WebOfScience code

https://www.webofscience.com/wos/woscc/full-record/WOS:000762108500001

Bibliographic citation

Pardos-Blas, J.R.; Tenorio, M.J.; Galindo, J.C.G.; Zardoya, R. (2022). Comparative venomics of the cryptic cone snail species Virroconus ebraeus and Virroconus judaeus. Mar. Drugs 20(2): 149. https://dx.doi.org/10.3390/md20020149

Topic

Marine

Is peer reviewed

true

Access rights

open access

Is accessible for free

true