{"refrec":{"BRefID":350469,"RR":"<b>Krasovec, G.; Hozumi, A.; Yoshida, T.; Obita, T.; Hamada, M.; Shiraishi, A.; Satake, H.; Horie, T.; Mori, H.; Sasakura, Y.</b> (2022). D-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate <i>Ciona</i>. <i>Science Advances 8(10)</i>: eabn3264. <a href=\"https://dx.doi.org/10.1126/sciadv.abn3264\" target=\"_blank\">https://dx.doi.org/10.1126/sciadv.abn3264</a>","BEntID":348165,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Science Advances 8(10)</i>: eabn3264. <a href=\"https://dx.doi.org/10.1126/sciadv.abn3264\" target=\"_blank\">https://dx.doi.org/10.1126/sciadv.abn3264</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Krasovec, G.; Hozumi, A.; Yoshida, T.; Obita, T.; Hamada, M.; Shiraishi, A.; Satake, H.; Horie, T.; Mori, H.; Sasakura, Y.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Krasovec, G. <i>et al.</i>","Englishabstract":"d-Serine, a free amino acid synthesized by serine racemase, is a coagonist of N-methyl-d-aspartate–type glutamate receptor (NMDAR). d-Serine in the mammalian central nervous system modulates glutamatergic transmission. Functions of d-serine in mammalian peripheral tissues such as skin have also been described. However, d-serine’s functions in nonmammals are unclear. Here, we characterized d-serine–dependent vesicle release from the epidermis during metamorphosis of the tunicate Ciona. d-Serine leads to the formation of a pocket that facilitates the arrival of migrating tissue during tail regression. NMDAR is the receptor of d-serine in the formation of the epidermal pocket. The epidermal pocket is formed by the release of epidermal vesicles’ content mediated by d-serine/NMDAR. This mechanism is similar to observations of keratinocyte vesicle exocytosis in mammalian skin. Our findings provide a better understanding of the maintenance of epidermal homeostasis in animals and contribute to further evolutionary perspectives of d-amino acid function among metazoans.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"D-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate <i>Ciona</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2022-03-17","DateCreate":"2022-03-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000800003800022","VABBcode":null,"OpenAcc":1,"DOI":"10.1126/sciadv.abn3264"},"refs":null,"anarec":{"AnaID":350469,"PubliDate":2022,"Pagination":"eabn3264","XtraPublOfAnaID":null,"ISBN":null,"Volume":"8","Issue":"10","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":248966,"SerRR":"Science Advances. 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