{"refrec":{"BRefID":350727,"RR":"<b>Zhang, P.; Xin, Y.; He, Y.; Tang, X.; Shen, C.; Wang, Q.; Lv, N.; Li, Y.; Hu, Q.; Xu, J.</b> (2022). Exploring a blue-light-sensing transcription factor to double the peak productivity of oil in <i>Nannochloropsis oceanica</i>. <i>Nature Comm. 13</i>: 1664. <a href=\"https://dx.doi.org/10.1038/s41467-022-29337-x\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-022-29337-x</a>","BEntID":348423,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Comm. 13</i>: 1664. <a href=\"https://dx.doi.org/10.1038/s41467-022-29337-x\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-022-29337-x</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Zhang, P.; Xin, Y.; He, Y.; Tang, X.; Shen, C.; Wang, Q.; Lv, N.; Li, Y.; Hu, Q.; Xu, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Zhang, P. <i>et al.</i>","Englishabstract":"Oleaginous microalgae can produce triacylglycerol (TAG) under stress, yet the underlying mechanism remains largely unknown. Here, we show that, in <i>Nannochloropsis oceanica</i>, a bZIP-family regulator NobZIP77 represses the transcription of a type-2 diacylgycerol acyltransferase encoding gene <i>NoDGAT2B</i> under nitrogen-repletion (N+), while nitrogen-depletion (N−) relieves such inhibition and activates <i>NoDGAT2B</i> expression and synthesis of TAG preferably from C16:1. Intriguingly, NobZIP77 is a sensor of blue light (BL), which reduces binding of NobZIP77 to the <i>NoDGAT2B-</i>promoter, unleashes NoDGAT2B and elevates TAG under N−. Under N+ and white light, <i>NobZIP77</i> knockout fully preserves cell growth rate and nearly triples TAG productivity. Moreover, exposing the <i>NobZIP77</i>-knockout line to BL under N− can double the peak productivity of TAG. These results underscore the potential of coupling light quality to oil synthesis in feedstock or bioprocess development.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Exploring a blue-light-sensing transcription factor to double the peak productivity of oil in <i>Nannochloropsis oceanica</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-03 01:31:58.851443","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2022-03-31","DateCreate":"2022-03-31","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000776008000007","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41467-022-29337-x"},"refs":null,"anarec":{"AnaID":350727,"PubliDate":2022,"Pagination":"1664","XtraPublOfAnaID":null,"ISBN":null,"Volume":"13","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":198717,"SerRR":"Nature Communications. 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