{"refrec":{"BRefID":350956,"RR":"<b>Sahonero Canavesi, D.X.; Villanueva, L.; Bale, N.J.; Bosviel, J.; Koenen, M.; Hopmans, E.C.; Sinninghe Damsté, J.S.</b> (2022). Changes in the distribution of membrane lipids during growth of <i>Thermotoga maritima</i> at different temperatures: Indications for the potential mechanism of biosynthesis of ether-bound diabolic acid (membrane-spanning) lipids. <i>Appl. Environ. Microbiol. 88(2)</i>. <a href=\"https://dx.doi.org/10.1128/aem.01763-21\" target=\"_blank\">https://dx.doi.org/10.1128/aem.01763-21</a>","BEntID":348657,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Appl. Environ. Microbiol. 88(2)</i>. <a href=\"https://dx.doi.org/10.1128/aem.01763-21\" target=\"_blank\">https://dx.doi.org/10.1128/aem.01763-21</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Sahonero Canavesi, D.X.; Villanueva, L.; Bale, N.J.; Bosviel, J.; Koenen, M.; Hopmans, E.C.; Sinninghe Damsté, J.S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Sahonero Canavesi, D.X. <i>et al.</i>","Englishabstract":"<p>    Membrane-spanning lipids are present in a wide variety of archaea, but they    are rarely in bacteria. Nevertheless, the (hyper)thermophilic members of    the order <em>Thermotogales</em> harbor tetraester, tetraether, and mixed    ether/ester membrane-spanning lipids mostly composed of core lipids derived    from diabolic acids, C<sub>30</sub>, C<sub>32</sub>, and C<sub>34</sub>    dicarboxylic acids with two adjacent mid-chain methyl substituents. Lipid    analysis of <em>Thermotoga maritima</em> across growth phases revealed a    decrease of the relative abundance of fatty acids together with an increase    of diabolic acids with independence of growth temperature. We also    identified isomers of C<sub>30</sub> and C<sub>32</sub> diabolic acids,    i.e., dicarboxylic acids with only one methyl group at C-15. Their    distribution suggests they are products of the condensation reaction but    are preferably produced when the length of the acyl chains is not optimal.    Compared with growth at the optimal temperature of 80°C, an increase of    glycerol ether-derived lipids was observed at 55°C. Our analysis only    detected diabolic acid-containing intact polar lipids with phosphoglycerol    (PG) head groups. Considering these findings, we hypothesize a biosynthetic    pathway for the synthesis of membrane-spanning lipids based on PG polar    lipid formation, suggesting that the protein catalyzing this process is a    membrane protein. We also identified, by genomic and protein domainanalyses, a gene coding for a putative plasmalogen synthase homologue in<em>T. maritima</em> that is also present in other bacteria producing    <em>sn</em>-1-alkyl ether lipids but not plasmalogens, suggesting it is    involved in the conversion of the ester-to-ether bond in the diabolic acids    bound in membrane-spanning lipids.</p>","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Changes in the distribution of membrane lipids during growth of <i>Thermotoga maritima</i> at different temperatures: Indications for the potential mechanism of biosynthesis of ether-bound diabolic acid (membrane-spanning) lipids","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-19 01:32:15.127071","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"membrane-spanning lipids; diabolic acid; biosynthesis; <i>Thermotoga maritima</i>; growth phase; ether lipids; <i>Thermotoga<i>; lipid biosynthesis","OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2023-05-17","DateCreate":"2022-04-07","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000748723400016","VABBcode":null,"OpenAcc":1,"DOI":"10.1128/aem.01763-21"},"refs":null,"anarec":{"AnaID":350956,"PubliDate":2022,"Pagination":null,"XtraPublOfAnaID":null,"ISBN":null,"Volume":"88","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42360,"SerRR":"Applied and Environmental Microbiology. 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