{"refrec":{"BRefID":352128,"RR":"<b>El Feky, S.E.; Abd El Hafez, M.S.M.; Abd El Moneim, N.A.; Ibrahim, H.A.H.; Okbah, M.A.; Ata, A.; El Sedfy, A.S.; Hussein, A.</b> (2022). Cytotoxic and antimicrobial activities of two new sesquiterpenoids from red sea brittle star <i>Ophiocoma dentata</i>. <i>NPG Scientific Reports 12(1)</i>: 8209. <a href=\"https://dx.doi.org/10.1038/s41598-022-12192-7\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-022-12192-7</a>","BEntID":349835,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 12(1)</i>: 8209. <a href=\"https://dx.doi.org/10.1038/s41598-022-12192-7\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-022-12192-7</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"El Feky, S.E.; Abd El Hafez, M.S.M.; Abd El Moneim, N.A.; Ibrahim, H.A.H.; Okbah, M.A.; Ata, A.; El Sedfy, A.S.; Hussein, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"El Feky, S.E. <i>et al.</i>","Englishabstract":"Bioactive compounds were extracted from a locally available brittle star; <i>Ophiocoma dentata</i>, collected from the Red Sea, Egypt. Two new sesquiterpenoids; 8, 11-epoxy-9(15)-himachaladiene-4-ol (O8-ophiocomane) and, 11-epoxy-9(15)-himachaladiene-4-ol (O7-ophiocomane) were isolated and characterized using appropriate techniques. Structure elucidation was estimated via 1D NMR, 2D NMR, FT-IR and mass spectroscopy analyses. The isolated compounds were tested for cytotoxic, antibacterial and antifungal activities. Pure compounds showed a dose dependent reduction in MCF-7 cells viability with LC50 of 103.5 and 59.5&nbsp;μg/ml for compounds 1 and 2 respectively compared to the chemotherapeutic drug cisplatin (47.4&nbsp;µg/ml). In vivo experiments showed that <i>O. dentate</i> extract significantly reduced tumor progression and improved hematological parameters and liver functions of tumor-bearing mice when administered either before or after tumor cells’ injection. The most remarkable antimicrobial effects of <i>O. dentate</i> crude extract were against <i>Staphylococcus aureus</i>, <i>Vibrio damsela</i> and <i>Pseudomonas</i> <i>aeruginosa</i> while the pure compounds showed activity against <i>P. aeruginosa</i> alone. Neither the crude extract nor the pure compounds have shown activity against <i>Aeromonas hydrophila</i>. These results indicates that <i>O. dentata</i> extract and newly isolated compounds have shown a promising cytotoxic, antiproliferative and antimicrobial activities that might be useful for pharmaceutical applications.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Cytotoxic and antimicrobial activities of two new sesquiterpenoids from red sea brittle star <i>Ophiocoma dentata</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-13 01:31:53.887696","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2022-05-24","DateCreate":"2022-05-24","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000815482800128","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41598-022-12192-7"},"refs":null,"anarec":{"AnaID":352128,"PubliDate":2022,"Pagination":"8209","XtraPublOfAnaID":null,"ISBN":null,"Volume":"12","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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