{"refrec":{"BRefID":352770,"RR":"<b>Pinheiro-Junior, E.L.; Kalina, R.; Gladkikh, I.; Leychenko, E.; Tytgat, J.; Peigneur, S.</b> (2022). A tale of toxin promiscuity: the versatile pharmacological effects of Hcr 1b-2 sea anemone peptide on voltage-gated ion channels. <i>Mar. Drugs 20(2)</i>: 147. <a href=\"https://dx.doi.org/10.3390/md20020147\" target=\"_blank\">https://dx.doi.org/10.3390/md20020147</a>","BEntID":350479,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 20(2)</i>: 147. <a href=\"https://dx.doi.org/10.3390/md20020147\" target=\"_blank\">https://dx.doi.org/10.3390/md20020147</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Pinheiro-Junior, E.L.; Kalina, R.; Gladkikh, I.; Leychenko, E.; Tytgat, J.; Peigneur, S.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Pinheiro-Junior, E.L. <i>et al.</i>","Englishabstract":"Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, <i>Heteractis crispa</i> species, also known as sebae anemone, is native to the Indo-Pacific area. As part of its venom components, the Hcr 1b-2 peptide was first described as an ASIC1a and ASIC3 inhibitor. Using <i>Xenopus laevis</i> oocytes and the two-electrode voltage-clamp technique, in the present work we describe the remarkable lack of selectivity of this toxin. Besides the acid-sensing ion channels previously described, we identified 26 new targets of this peptide, comprising 14 voltage-gated potassium channels, 9 voltage-gated sodium channels, and 3 voltage-gated calcium channels. Among them, Hcr 1b-2 is the first sea anemone peptide described to interact with isoforms from the Kv7 family and T-type Cav channels. Taken together, the diversity of Hcr 1b-2 targets turns this toxin into an interesting tool to study different types of ion channels, as well as a prototype to develop new and more specific ion channel ligands.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"A tale of toxin promiscuity: the versatile pharmacological effects of Hcr 1b-2 sea anemone peptide on voltage-gated ion channels","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-21 01:33:09.802263","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Heteractis crispa; APETx-like peptides; sea anemone; ion channels","OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2022-06-22","DateCreate":"2022-06-21","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000765074500001","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md20020147"},"refs":null,"anarec":{"AnaID":352770,"PubliDate":2022,"Pagination":"147","XtraPublOfAnaID":null,"ISBN":null,"Volume":"20","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. 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