{"refrec":{"BRefID":353282,"RR":"<b>Deryckere, A.; Styfhals, R.; Elagoz, A.M.; Maes, G.E.; Seuntjens, E.</b> (2021). Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain. <i>eLIFE 10</i>: e69161. <a href=\"https://dx.doi.org/10.7554/eLife.69161\" target=\"_blank\">https://dx.doi.org/10.7554/eLife.69161</a>","BEntID":350991,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>eLIFE 10</i>: e69161. <a href=\"https://dx.doi.org/10.7554/eLife.69161\" target=\"_blank\">https://dx.doi.org/10.7554/eLife.69161</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Deryckere, A.; Styfhals, R.; Elagoz, A.M.; Maes, G.E.; Seuntjens, E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Deryckere, A. <i>et al.</i>","Englishabstract":"Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in <i>Octopus vulgaris</i> embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors <i>achaete-scute</i> or <i>neurogenin</i>, is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid <i>Doryteuthis pealeii</i>. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2022-07-05","DateCreate":"2022-07-01","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000689519000001","VABBcode":null,"OpenAcc":1,"DOI":"10.7554/eLife.69161"},"refs":null,"anarec":{"AnaID":353282,"PubliDate":2021,"Pagination":"e69161","XtraPublOfAnaID":null,"ISBN":null,"Volume":"10","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":240535,"SerRR":"eLIFE. eLife Sciences Publications: Cambridge.  e-ISSN 2050-084X","StandardTitleSer":"eLIFE","ISSN":null,"AbbrevSer":null,"StandardTitleMon":null,"StartPage":32,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Deryckere","Firstname":"Astrid","Initials":"A.","Affiliation":"Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":350991,"AutID":414394,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Departement Biologie; Afdeling Dierenfysiologie en Neurobiologie; Research group of Developmental Neurobiology","ORCID":"0000-0001-6227-7759","PersID":37227,"InsID":14394},{"AutName":"Styfhals","Firstname":"Ruth","Initials":"R.","Affiliation":"Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":350991,"AutID":414396,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Departement Biologie; Afdeling Dierenfysiologie en Neurobiologie; Research group of Developmental Neurobiology","ORCID":null,"PersID":37634,"InsID":14394},{"AutName":"Elagoz","Firstname":"Ali","Initials":"A.M.","Affiliation":"Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":350991,"AutID":493226,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Departement Biologie; Afdeling Dierenfysiologie en Neurobiologie; Research group of Developmental Neurobiology","ORCID":"0000-0002-1639-0619","PersID":38671,"InsID":14394},{"AutName":"Maes","Firstname":"Gregory","Initials":"G.E.","Affiliation":"Center for Human Genetics, UZ Leuven- Genomics Core, KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":350991,"AutID":370369,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":"0000-0002-1531-7321","PersID":2346,"InsID":null},{"AutName":"Seuntjens","Firstname":"Eve","Initials":"E.","Affiliation":"Laboratory of Developmental Neurobiology, Department of Biology, KU Leuven","Discriminator":null,"CorporateFlag":0,"BEntID":350991,"AutID":414395,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":"KU Leuven; Departement Biologie; Afdeling Dierenfysiologie en Neurobiologie; Research group of Developmental Neurobiology","ORCID":"0000-0002-0126-461X","PersID":37228,"InsID":14394}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":378620,"LibID":36,"BRefID":353282,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"378620","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"eLife Sciences Publications","City":"Cambridge"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":[{"TaxTerm":"Doryteuthis pealeii"},{"TaxTerm":"Octopus vulgaris"}],"geotermsASFA":null,"collections":[{"Collection":"OMA - Open Marien Archief","ShortName":"OMA"}],"conf":null,"proj":null,"Physdatasets":null,"spcols":{"222":{"SpName":"BMB - Belgische Mariene Bibliografie","SpColID":222,"ParSpColID":null,"TopParID":null,"ShortName":"BMB","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"BMB"},"221":{"SpName":"OMA - Open Marien Archief","SpColID":221,"ParSpColID":null,"TopParID":null,"ShortName":"OMA","URLLocation":null,"LibID":36,"OpenRepoFlag":1,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"OMA"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":350991,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":350991,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.7554/eLife.69161","externalID":"10.7554/eLife.69161","URLTypeCode":"DOI","URLID":103999,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":[{"TaxTerm":"Doryteuthis pealeii","AphiaID":574541,"TaxtID":48518},{"TaxTerm":"Octopus vulgaris","AphiaID":140605,"TaxtID":39491}],"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":[{"TaxTerm":"Doryteuthis pealeii","DutchTerm":null,"AphiaID":574541,"TaxtID":48518},{"TaxTerm":"Octopus vulgaris","DutchTerm":null,"AphiaID":140605,"TaxtID":39491}],"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Bouchti, Zohra, Z.","newSesDate":{"date":"2022-07-01 14:21:55.743000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2022-07-05 08:43:24.880000","timezone_type":3,"timezone":"Europe/Brussels"}}}