{"refrec":{"BRefID":353302,"RR":"<b>Belova, L.; Fujii, Y.; Cleys, P.; Śmiełowska, M.; Haraguchi, K.; Covaci, A.</b> (2021). Identification of novel halogenated naturally occurring compounds in marine biota by high-resolution mass spectrometry and combined screening approaches. <i>Environ. Pollut. 289</i>: 117933. <a href=\"https://dx.doi.org/10.1016/j.envpol.2021.117933\" target=\"_blank\">https://dx.doi.org/10.1016/j.envpol.2021.117933</a>","BEntID":351011,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Environ. Pollut. 289</i>: 117933. <a href=\"https://dx.doi.org/10.1016/j.envpol.2021.117933\" target=\"_blank\">https://dx.doi.org/10.1016/j.envpol.2021.117933</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Belova, L.; Fujii, Y.; Cleys, P.; Śmiełowska, M.; Haraguchi, K.; Covaci, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Belova, L. <i>et al.</i>","Englishabstract":"Marine animals, plants or bacteria are a source of bioactive naturally-occurring halogenated compounds (NHCs) such as bromophenols (BPs), bromoanisoles (BAs) and hydroxylated or methoxylated analogues of polybrominated diphenyl ethers (HO-PBDEs, MeO-PBDEs) and bromobiphenyls (HO-BBs, MeO-BBs). This study applied a comprehensive screening approach using liquid chromatography high-resolution mass spectrometry and combining target, suspect and non-target screening with the aim to identify new hydroxylated NHCs which might be missed by commonly applied gas chromatographic methods. 24 alga samples, 4 sea sponge samples and 7 samples of other invertebrates were screened. Target screening was based on 19 available reference standards of BPs, (di)OH-BDEs and diOH-BBs and yielded seven unequivocally identified compounds. 6-OH-BDE47 was the most frequently detected compound with a detection frequency of 31%. Suspect screening yielded two additional compounds identified in alga samples as well as 17 and 8 compounds identified in sea sponge samples of <i>Lamellodysidea</i> sp. and <i>Callyspongia</i> sp., respectively. The suspect screening results presented here confirmed the findings of previous studies conducted on sea sponge samples of <i>Lamellodysidea</i> sp. and <i>Callyspongia</i> sp. Additionally, in <i>Lamellodysidea</i> sp. and <i>Callyspongia</i> sp. 13 and 4 newly identified NHCs are reported including heptabrominated diOH-BDE, monochlorinated pentabrominated diOH-BDE, hexabrominated OH–MeO-BDE and others. Non-target screening allowed the identification of 31 and 20 polyhalogenated compounds in <i>Lamellodysidea</i> sp. and <i>Callyspongia</i> sp. samples, respectively. Based on the obtained fragmentation spectra, polybrominated dihydroxylated diphenoxybenzenes (diOH-PBDPBs), such as hepta-, octa- and nonabrominated diOH-BDPBs, could be identified in both species. To our knowledge, this study is the first report on the environmental presence of OH-PBDPBs.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Identification of novel halogenated naturally occurring compounds in marine biota by high-resolution mass spectrometry and combined screening approaches","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-19 01:32:16.439674","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Naturally-occurring halogenated compounds; Seafood; Sea sponges; HO-BDE; Polybrominated dihydroxylated diphenoxybenzenes; Target screening;  Suspect and non-target screening","OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2022-10-06","DateCreate":"2022-07-01","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000696803400005","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.envpol.2021.117933"},"refs":null,"anarec":{"AnaID":353302,"PubliDate":2021,"Pagination":"117933","XtraPublOfAnaID":null,"ISBN":null,"Volume":"289","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42834,"SerRR":"Environmental Pollution. 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