{"refrec":{"BRefID":354027,"RR":"<b>Martens, N.; Schepers, M.; Zhang, N.; Leijten, F.; Voortman, G.; Tiane, A.; Rombaut, B.; Poisquet, J.; van de Sande, N.; Kerksiek, A.; Kuipers, F.; Jonker, J.W.; Liu, H.; Lütjohann, D.; Vanmierlo, T.; Mulder, M.T.</b> (2021). 24(S)-saringosterol prevents cognitive decline in a mouse model for Alzheimer's disease. <i>Mar. Drugs 19(4)</i>: 190. <a href=\"https://dx.doi.org/10.3390/md19040190\" target=\"_blank\">https://dx.doi.org/10.3390/md19040190</a>","BEntID":351740,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Mar. Drugs 19(4)</i>: 190. <a href=\"https://dx.doi.org/10.3390/md19040190\" target=\"_blank\">https://dx.doi.org/10.3390/md19040190</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Martens, N.; Schepers, M.; Zhang, N.; Leijten, F.; Voortman, G.; Tiane, A.; Rombaut, B.; Poisquet, J.; van de Sande, N.; Kerksiek, A.; Kuipers, F.; Jonker, J.W.; Liu, H.; Lütjohann, D.; Vanmierlo, T.; Mulder, M.T.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Martens, N. <i>et al.</i>","Englishabstract":"We recently found that dietary supplementation with the seaweed <i>Sargassum fusiforme</i>, containing the preferential LXRβ-agonist 24(S)-saringosterol, prevented memory decline and reduced amyloid-β (Aβ) deposition in an Alzheimer’s disease (AD) mouse model without inducing hepatic steatosis. Here, we examined the effects of 24(S)-saringosterol as a food additive on cognition and neuropathology in AD mice. Six-month-old male APPswePS1ΔE9 mice and wildtype C57BL/6J littermates received 24(S)-saringosterol (0.5 mg/25 g body weight/day) (APPswePS1ΔE9 n = 20; C57BL/6J n = 19) or vehicle (APPswePS1ΔE9 n = 17; C57BL/6J n = 19) for 10 weeks. Cognition was assessed using object recognition and object location tasks. Sterols were analyzed by gas chromatography/mass spectrometry, Aβ and inflammatory markers by immunohistochemistry, and gene expression by quantitative real-time PCR. Hepatic lipids were quantified after Oil-Red-O staining. Administration of 24(S)-saringosterol prevented cognitive decline in APPswePS1ΔE9 mice without affecting the Aβ plaque load. Moreover, 24(S)-saringosterol prevented the increase in the inflammatory marker Iba1 in the cortex of APPswePS1ΔE9 mice (p < 0.001). Furthermore, 24(S)-saringosterol did not affect the expression of lipid metabolism-related LXR-response genes in the hippocampus nor the hepatic neutral lipid content. Thus, administration of 24(S)-saringosterol prevented cognitive decline in APPswePS1ΔE9 mice independent of effects on Aβ load and without adverse effects on liver fat content. The anti-inflammatory effects of 24(S)-saringosterol may contribute to the prevention of cognitive decline.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"24(S)-saringosterol prevents cognitive decline in a mouse model for Alzheimer's disease","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-17 01:32:45.401058","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Alzheimer’s disease; seaweed; Sargassum fusiforme; phytosterols; cholesterol metabolism","OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2022-10-05","DateCreate":"2022-07-25","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000643197300001","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/md19040190"},"refs":null,"anarec":{"AnaID":354027,"PubliDate":2021,"Pagination":"190","XtraPublOfAnaID":null,"ISBN":null,"Volume":"19","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":113252,"SerRR":"Marine Drugs. 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