{"refrec":{"BRefID":354029,"RR":"<b>Nguyen, N.D.; Pande, G.S.J.; Kashem, M.A.; Baruah, K.; Bossier, P.</b> (2021). Acute hepatopancreatic necrosis disease (AHPND) toxin degradation by <i>Bacillus subtilis</i> DSM33018. <i>Aquaculture 540</i>: 736634. <a href=\"https://dx.doi.org/10.1016/j.aquaculture.2021.736634\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquaculture.2021.736634</a>","BEntID":351742,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquaculture 540</i>: 736634. <a href=\"https://dx.doi.org/10.1016/j.aquaculture.2021.736634\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquaculture.2021.736634</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Nguyen, N.D.; Pande, G.S.J.; Kashem, M.A.; Baruah, K.; Bossier, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Nguyen, N.D. <i>et al.</i>","Englishabstract":"Early mortality syndrome (EMS) or acute hepatopancreatic necrosis disease (AHPND), results in significant mortality in penaeid shrimp aquaculture. AHPND is caused by toxins secreted by pathogenic strains of <i>Vibrio parahaemolyticus</i>, that have acquired a unique 63–70 kb AHPND-associated plasmid (pVA1). This plasmid encodes the binary PirA/B<sup>VP</sup> toxins that consist of two subunits PirA<sup>VP</sup> and PirB<sup>VP</sup>. Consequently, the degradation of these toxins might be a valid strategy to control or mitigate AHPND. There is literature-based evidence that the application of <i>Bacillus</i> improves shrimp survival upon challenge with pathogenic <i>V. parahaemolyticus</i>. In this study, <i>Bacillus subtilis</i> DSM33018 strain was shown to degrade AHPND toxins in vitro, as detected by Western blots. Further, an in vivo challenge test, using gnotobiotically cultured brine shrimp <i>Artemia franciscana</i> exposed to PirA/B<sup>VP</sup> toxins, the DSM33018 <i>Bacillus</i> strain could completely alleviate toxicity. This finding indicates that mitigation of AHPND might include <i>Bacillus</i>-based degradation of Pir<sup>VP</sup> toxins.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Acute hepatopancreatic necrosis disease (AHPND) toxin degradation by <i>Bacillus subtilis</i> DSM33018","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:32:52.928458","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"AHPND; Bacillus subtilis; PirA/BVP toxin; Shrimp; Degradation","OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2022-10-05","DateCreate":"2022-07-25","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000648540900014","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquaculture.2021.736634"},"refs":null,"anarec":{"AnaID":354029,"PubliDate":2021,"Pagination":"736634","XtraPublOfAnaID":null,"ISBN":null,"Volume":"540","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42190,"SerRR":"Aquaculture. 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