{"refrec":{"BRefID":355027,"RR":"<b>Sachslehner, A.; Zieger, E.; Calcino, A.; Wanninger, A.</b> (2021). <i>HES</i> and <i>Mox</i> genes are expressed during early mesoderm formation in a mollusk with putative ancestral features. <i>NPG Scientific Reports 11(1)</i>: 18030. <a href=\"https://dx.doi.org/10.1038/s41598-021-96711-y\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-021-96711-y</a>","BEntID":352740,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 11(1)</i>: 18030. <a href=\"https://dx.doi.org/10.1038/s41598-021-96711-y\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-021-96711-y</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Sachslehner, A.; Zieger, E.; Calcino, A.; Wanninger, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Sachslehner, A. <i>et al.</i>","Englishabstract":"The mesoderm is considered the youngest of the three germ layers. Although its morphogenesis has been studied in some metazoans, the molecular components underlying this process remain obscure for numerous phyla including the highly diverse Mollusca. Here, expression of <i>Hairy and enhancer of split</i> (<i>HES</i>), <i>Mox</i>, and <i>myosin heavy chain</i> (<i>MHC</i>) was investigated in <i>Acanthochitona fascicularis</i>, a representative of Polyplacophora with putative ancestral molluscan features. While <i>AfaMHC</i> is expressed throughout myogenesis, <i>AfaMox1</i> is only expressed during early stages of mesodermal band formation and in the ventrolateral muscle, an autapomorphy of the polyplacophoran trochophore. Comparing our findings to previously published data across Metazoa reveals <i>Mox</i> expression in the mesoderm in numerous bilaterians including gastropods, polychaetes, and brachiopods. It is also involved in myogenesis in molluscs, annelids, tunicates, and craniates, suggesting a dual role of <i>Mox</i> in mesoderm and muscle formation in the last common bilaterian ancestor. <i>AfaHESC2</i> is expressed in the ectoderm of the polyplacophoran gastrula and later in the mesodermal bands and in putative neural tissue, whereas <i>AfaHESC7</i> is expressed in the trochoblasts of the gastrula and during foregut formation. This confirms the high developmental variability of HES gene expression and demonstrates that <i>Mox</i> and <i>HES</i> genes are pleiotropic.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"<i>HES</i> and <i>Mox</i> genes are expressed during early mesoderm formation in a mollusk with putative ancestral features","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-08 01:31:28.050869","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2021,"MonPub":null,"DateUpdate":"2022-08-22","DateCreate":"2022-08-22","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000695272000068","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41598-021-96711-y"},"refs":null,"anarec":{"AnaID":355027,"PubliDate":2021,"Pagination":"18030","XtraPublOfAnaID":null,"ISBN":null,"Volume":"11","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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