{"refrec":{"BRefID":355082,"RR":"<b>Sui, Y.; Muys, M.; Van de Waal, D.B.; D'Adamo, S.; Vermeir, P.; Fernandes, T.V.; Vlaeminck, S.E.</b> (2019). Enhancement of co-production of nutritional protein and carotenoids in <i>Dunaliella salina</i> using a two-phase cultivation assisted by nitrogen level and light intensity. <i>Bioresour. Technol. 287</i>: 121398. <a href=\"https://dx.doi.org/10.1016/j.biortech.2019.121398\" target=\"_blank\">https://dx.doi.org/10.1016/j.biortech.2019.121398</a>","BEntID":352795,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Bioresour. Technol. 287</i>: 121398. <a href=\"https://dx.doi.org/10.1016/j.biortech.2019.121398\" target=\"_blank\">https://dx.doi.org/10.1016/j.biortech.2019.121398</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Sui, Y.; Muys, M.; Van de Waal, D.B.; D'Adamo, S.; Vermeir, P.; Fernandes, T.V.; Vlaeminck, S.E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Sui, Y. <i>et al.</i>","Englishabstract":"Microalga <em>Dunaliella salina</em> is known for its carotenogenesis. At the same time, it can also produce high-quality protein. The optimal conditions for <em>D. salina</em> to co-produce intracellular pools of both compounds, however, are yet unknown. This study investigated a two-phase cultivation strategy to optimize combined high-quality protein and carotenoid production of <em>D. salina</em>. In phase-one, a gradient of nitrogen concentrations was tested. In phase-two, effects of nitrogen pulse and high illumination were tested. Results reveal optimized protein quantity, quality (expressed as essential amino acid index EAAI) and carotenoids content in a two-phase cultivation, where short nitrogen starvation in phase-one was followed by high illumination during phase-two. Adopting this strategy, productivities of protein, EAA and carotenoids reached 22, 7 and 3 mg/L/d, respectively, with an EAAI of 1.1. The quality of this biomass surpasses FAO/WHO standard for human nutrition, and the observed level of β-carotene presents high antioxidant pro-vitamin A activity.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Enhancement of co-production of nutritional protein and carotenoids in <i>Dunaliella salina</i> using a two-phase cultivation assisted by nitrogen level and light intensity","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-18 01:32:30.522404","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Single-cell protein; Pigment; Nitrogen limitation; Food; Microalgae","OtherDescriptors":null,"Notes":null,"AnaPub":2019,"MonPub":null,"DateUpdate":"2022-08-23","DateCreate":"2022-08-23","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000469414500008","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.biortech.2019.121398"},"refs":null,"anarec":{"AnaID":355082,"PubliDate":2019,"Pagination":"121398","XtraPublOfAnaID":null,"ISBN":null,"Volume":"287","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42269,"SerRR":"Bioresource Technology. 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