{"refrec":{"BRefID":355502,"RR":"<b>Poehn, B.; Krishnan, S.; Zurl, M.; Coric, A.; Rokvic, D.; Häfker, N.S.; Jaenicke, E.; Arboleda, E.; Orel, L.; Raible, F.; Wolf, E.; Tessmar-Raible, K.</b> (2022). A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment. <i>Nature Comm. 13(1)</i>: 5220. <a href=\"https://dx.doi.org/10.1038/s41467-022-32562-z\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-022-32562-z</a>","BEntID":353215,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Comm. 13(1)</i>: 5220. <a href=\"https://dx.doi.org/10.1038/s41467-022-32562-z\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-022-32562-z</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Poehn, B.; Krishnan, S.; Zurl, M.; Coric, A.; Rokvic, D.; Häfker, N.S.; Jaenicke, E.; Arboleda, E.; Orel, L.; Raible, F.; Wolf, E.; Tessmar-Raible, K.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Poehn, B. <i>et al.</i>","Englishabstract":"The moon’s monthly cycle synchronizes reproduction in countless marine organisms. The mass-spawning bristle worm <i>Platynereis dumerilii</i> uses an endogenous monthly oscillator set by full moon to phase reproduction to specific days. But how do organisms recognize specific moon phases? We uncover that the light receptor L-Cryptochrome (L-Cry) discriminates between different moonlight durations, as well as between sun- and moonlight. A biochemical characterization of purified L-Cry protein, exposed to naturalistic sun- or moonlight, reveals the formation of distinct sun- and moonlight states characterized by different photoreduction- and recovery kinetics of L-Cry’s co-factor Flavin Adenine Dinucleotide. In <i>Platynereis</i>, L-Cry’s sun- versus moonlight states correlate with distinct subcellular localizations, indicating different signaling. In contrast, r-Opsin1, the most abundant ocular opsin, is not required for monthly oscillator entrainment. Our work reveals a photo-ecological concept for natural light interpretation involving a “valence interpreter” that provides entraining photoreceptor(s) with light source and moon phase information.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"A Cryptochrome adopts distinct moon- and sunlight states and functions as sun- versus moonlight interpreter in monthly oscillator entrainment","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-05-07 01:33:19.674297","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2022-09-16","DateCreate":"2022-09-16","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000850348400006","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41467-022-32562-z"},"refs":null,"anarec":{"AnaID":355502,"PubliDate":2022,"Pagination":"5220","XtraPublOfAnaID":null,"ISBN":null,"Volume":"13","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":198717,"SerRR":"Nature Communications. 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