{"refrec":{"BRefID":355928,"RR":"<b>Zhang, S.; Yang, Q.; Fu, S.; Janssen, C.R.; Eggermont, M.; Defoirdt, T.</b> (2022). Indole decreases the virulence of the bivalve model pathogens <i>Vibrio tasmaniensis</i> LGP32 and <i>Vibrio crassostreae</i> J2-9. <i>NPG Scientific Reports 12(1)</i>: 5749. <a href=\"https://dx.doi.org/10.1038/s41598-022-09799-1\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-022-09799-1</a>","BEntID":353642,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>NPG Scientific Reports 12(1)</i>: 5749. <a href=\"https://dx.doi.org/10.1038/s41598-022-09799-1\" target=\"_blank\">https://dx.doi.org/10.1038/s41598-022-09799-1</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Zhang, S.; Yang, Q.; Fu, S.; Janssen, C.R.; Eggermont, M.; Defoirdt, T.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Zhang, S. <i>et al.</i>","Englishabstract":"Indole signaling plays an important role in bacterial pathogenesis. In this study, the impact of indole on biofilm formation, swimming and swarming motility were explored in <i>Vibrio tasmaniensis</i> LGP32 and <i>Vibrio crassostreae</i> J2-9, two model pathogens of bivalves. The results showed that indole decreased swimming and swarming motility in both strains, and decreased biofilm formation in <i>V. crassostreae</i> J2-9. Furthermore, indole affected a large number of genes at RNA level, including genes related to metabolism, ABC transporters, flagellar assembly, chemotaxis, and response regulators. Finally, the bacterial virulence towards mussel larvae was decreased by pretreatment with indole in both <i>V. tasmaniensis</i> LGP32 and <i>V. crassostreae</i> J2-9. After 5&nbsp;days, the survival rate of mussel larvae increased 2.4-fold and 2.8-fold in mussel larvae challenged with <i>V. tasmaniensis</i> LGP32 pretreated with 200&nbsp;µM and 500&nbsp;µM indole, respectively. The survival rate of mussel larvae increased 1.5-fold and 1.9-fold in mussel larvae challenged with <i>V. crassostreae</i> J2-9 pretreated with 200&nbsp;µM and 500&nbsp;µM indole, respectively. These data indicate that indole has a significant impact on the virulence of <i>V. tasmaniensis</i> LGP32 and <i>V. crassostreae</i> J2-9, and indole signaling could be a promising target for antivirulence therapy.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Indole decreases the virulence of the bivalve model pathogens <i>Vibrio tasmaniensis</i> LGP32 and <i>Vibrio crassostreae</i> J2-9","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-20 01:32:52.954050","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2022-10-03","DateCreate":"2022-10-03","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000780164200074","VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41598-022-09799-1"},"refs":null,"anarec":{"AnaID":355928,"PubliDate":2022,"Pagination":"5749","XtraPublOfAnaID":null,"ISBN":null,"Volume":"12","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":208093,"SerRR":"Scientific Reports (Nature Publishing Group). 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