{"refrec":{"BRefID":356224,"RR":"<b>Kuruppuarachchi, S.U.; Gunathilake, V.K.</b> (2022). Zoo-chemical profiling, <i>in vivo</i> toxicity and <i>in vitro</i> anti-inflammatory properties of <i>Luffariella herdmani</i> marine sponge extract. <i>Journal of Advanced Biotechnology and Experimental Therapeutics 5(2)</i>: 269-282. <a href=\"https://dx.doi.org/10.5455/jabet.2022.d114\" target=\"_blank\">https://dx.doi.org/10.5455/jabet.2022.d114</a>","BEntID":353938,"PublicFlag":1,"CheckedFlag":0,"wosflag":0,"vabbflag":0,"RefStringPartII":". <i>Journal of Advanced Biotechnology and Experimental Therapeutics 5(2)</i>: 269-282. <a href=\"https://dx.doi.org/10.5455/jabet.2022.d114\" target=\"_blank\">https://dx.doi.org/10.5455/jabet.2022.d114</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kuruppuarachchi, S.U.; Gunathilake, V.K.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kuruppuarachchi, S.U.; Gunathilake, V.K.","Englishabstract":"The present study investigates the zoo-chemical profiling, anti-inflammatory, and radical scavenging activities of <i>Luffariella herdmani</i> marine sponge extract. The sponge crude extract (SCE) was prepared by methanol/dichloromethane extraction, followed by rotary evaporation. The percentage yield was calculated, and the zoo-chemicals were investigated by standard methods, while anti-inflammatory activity was tested by protein denaturation assay. Radical scavenging activity of the SCE was tested against 2, 2-diphenyl-1-picrylhydrazy (DPPH), nitric oxide (NO) and peroxide radicals, while in vivo toxicity was evaluated by the <i>Artemia salina</i> lethality assay. The results indicated the presence of terpenoids, alkaloids, anthraquinones, unsaturated sterols, sterols, and saponins in the SCE while flavanoids, quinones, tannins, and phenols were absent. In vitro anti-inflammatory activity against protein denaturation with IC<sub>50</sub> of 58.54 μg/ml was evidenced while radical scavenging activity was not reported. The SCE was toxic to <i>A. salina</i> larvae with LC<sub>50</sub> of 14.34 μg/ml. In conclusion, <i>L. herdmani</i> sponge extract possesses <i>in vitro</i> anti-inflammatory, <i>in vivo</i> toxic properties, yet radical scavenging activity was absent. The presence of terpenoids, alkaloids, anthraquinones, unsaturated sterols, sterols, and saponins with reported anti-inflammatory properties is suggestive of the use of <i>L. herdmani</i> sponge extract as an anti-inflammatory drug lead.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Zoo-chemical profiling, <i>in vivo</i> toxicity and <i>in vitro</i> anti-inflammatory properties of <i>Luffariella herdmani</i> marine sponge extract","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2022-10-11","DateCreate":"2022-10-11","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1,"DOI":"10.5455/jabet.2022.d114"},"refs":null,"anarec":{"AnaID":356224,"PubliDate":2022,"Pagination":"269-282","XtraPublOfAnaID":null,"ISBN":null,"Volume":"5","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":356223,"SerRR":"Journal of Advanced Biotechnology and Experimental Therapeutics. Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology: Bangladesh.  e-ISSN 2616-4760","StandardTitleSer":"Journal of Advanced Biotechnology and Experimental Therapeutics","ISSN":null,"AbbrevSer":null,"StandardTitleMon":null,"StartPage":269,"Pages":14,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Kuruppuarachchi","Firstname":"Sashini","Initials":"S.U.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":353938,"AutID":505907,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Gunathilake","Firstname":"Varuni","Initials":"V.K.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":353938,"AutID":505908,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":382098,"LibID":36,"BRefID":356224,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"382098","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology","City":"Bangladesh"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":[{"TaxTerm":"Artemia salina"},{"TaxTerm":"Luffariella herdmani"}],"geotermsASFA":null,"collections":[{"Collection":"VLIZ Acknowledged Publications","ShortName":"VLIZ ackn"}],"conf":null,"proj":null,"Physdatasets":null,"spcols":{"941":{"SpName":"LifeWatch Species Information Backbone","SpColID":941,"ParSpColID":39,"TopParID":39,"ShortName":"LifeWatch Species Information Backbone","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone"},"39":{"SpName":"VLIZ Acknowledged Publications","SpColID":39,"ParSpColID":null,"TopParID":null,"ShortName":"VLIZ ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"VLIZ ackn"},"507":{"SpName":"World Register of Marine Species","SpColID":507,"ParSpColID":null,"TopParID":null,"ShortName":"WoRMS website","URLLocation":null,"LibID":null,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"WoRMS website"},"915":{"SpName":"World Register of Marine Species (WoRMS) acknowledged","SpColID":915,"ParSpColID":941,"TopParID":39,"ShortName":"WoRMS ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone/WoRMS ackn"},"947":{"SpName":"WoRMS ackn - direct reference","SpColID":947,"ParSpColID":915,"TopParID":39,"ShortName":"WoRMS ackn - direct","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone/WoRMS ackn/WoRMS ackn - direct"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":353938,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":353938,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.5455/jabet.2022.d114","externalID":"10.5455/jabet.2022.d114","URLTypeCode":"DOI","URLID":106425,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":[{"TaxTerm":"Artemia salina","AphiaID":480246,"TaxtID":22802},{"TaxTerm":"Luffariella herdmani","AphiaID":165364,"TaxtID":53123}],"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":[{"TaxTerm":"Artemia salina","DutchTerm":null,"AphiaID":480246,"TaxtID":22802},{"TaxTerm":"Luffariella herdmani","DutchTerm":null,"AphiaID":165364,"TaxtID":53123}],"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Bouchti, Zohra, Z.","newSesDate":{"date":"2022-10-11 08:21:18.990000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Bouchti, Zohra, Z.","updSesDate":{"date":"2022-10-11 08:21:18.990000","timezone_type":3,"timezone":"Europe/Brussels"}}}