{"refrec":{"BRefID":356574,"RR":"<b>Lillie, M.A.; Vogl, A.W.; Jennings, S.G.; Raverty, S.; Shadwick, R.E.</b> (2022). Retia mirabilia: Protecting the cetacean brain from locomotion-generated blood pressure pulses. <i>Science (Wash.) 377(6613)</i>: 1452-1456. <a href=\"https://dx.doi.org/10.1126/science.abn3315\" target=\"_blank\">https://dx.doi.org/10.1126/science.abn3315</a>","BEntID":354289,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Science (Wash.) 377(6613)</i>: 1452-1456. <a href=\"https://dx.doi.org/10.1126/science.abn3315\" target=\"_blank\">https://dx.doi.org/10.1126/science.abn3315</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Lillie, M.A.; Vogl, A.W.; Jennings, S.G.; Raverty, S.; Shadwick, R.E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Lillie, M.A. <i>et al.</i>","Englishabstract":"Cetaceans have massive vascular plexuses (retia mirabilia) whose function is unknown. All cerebral blood flow passes through these retia, and we hypothesize that they protect cetacean brains from locomotion-generated pulsatile blood pressures. We propose that cetaceans have evolved a pulse-transfer mechanism that minimizes pulsatility in cerebral arterial-to-venous pressure differentials without dampening the pressure pulses themselves. We tested this hypothesis using a computational model based on morphology from 11 species and found that the large arterial capacitance in the retia, coupled with the small extravascular capacitance in the cranium and vertebral canal, could protect the cerebral vasculature from 97% of systemic pulsatility. Evolution of the retial complex in cetaceans—likely linked to the development of dorsoventral fluking—offers a distinctive solution to adverse locomotion-generated vascular pulsatility.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Retia mirabilia: Protecting the cetacean brain from locomotion-generated blood pressure pulses","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-15 01:33:45.633366","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2022-10-20","DateCreate":"2022-10-20","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000887934300043","VABBcode":null,"OpenAcc":0,"DOI":"10.1126/science.abn3315"},"refs":null,"anarec":{"AnaID":356574,"PubliDate":2022,"Pagination":"1452-1456","XtraPublOfAnaID":null,"ISBN":null,"Volume":"377","Issue":"6613","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43776,"SerRR":"Science (Washington). American Association for the Advancement of Science: New York, N.Y.  ISSN 0036-8075; e-ISSN 1095-9203","StandardTitleSer":"Science (Washington)","ISSN":"0036-8075","AbbrevSer":"Science (Wash.)","StandardTitleMon":null,"StartPage":1452,"Pages":5,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":[{"YBRefID":355678,"RefStrFull":"<b>Williams, T.M.</b> (2022). Recasting the whale’s wonderful net. <i>Science (Wash.) 377(6613)</i>: 1378-1379. <a href=\"https://dx.doi.org/10.1126/science.ade3117\" target=\"_blank\">https://dx.doi.org/10.1126/science.ade3117</a>","RelID":4,"Relation":"Related to","StandardTitle":"Recasting the whale’s wonderful net"}],"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Lillie","Firstname":"Margo","Initials":"M.A.","Affiliation":"Univ British Columbia, Fac Sci, Dept Zool, Vancouver, BC V6T 1Z4, Canada.","Discriminator":null,"CorporateFlag":0,"BEntID":354289,"AutID":305361,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Vogl","Firstname":"A. 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