Document of bibliographic reference 359950

BibliographicReference record

Type

Bibliographic resource

Type of document

Journal article

BibLvlCode

AS

Title

First report of steroid derivatives isolated from starfish Acanthaster planci with anti-bacterial, anti-cancer and anti-diabetic activities

Abstract

Chemical studies on Acanthaster planci have afforded two steroids, 5α-cholesta-24-en-3β,20β-diol-23-one (1) and 5α-cholesta-9(11)-en-3β, 20β-diol (2). Structures compounds 1 and 2 were determined with the help of spectroscopic studies. Compound 1 showed strong antibacterial activity (21.0 ± 0.06 mm) against P. aeruginosa. Compounds 1 and 2 were also active against human breast carcinoma cells (MCF-7) with LC₅₀ values of 49 ± 1.6 and 57.5 ± 1.5 μg/ml, respectively. This bioactivity was comparable to the currently used anticancer agent, cisplatin (LC₅₀ 46 ± 1.1 µg/ml). Compounds 1 and 2 exhibited anti-α-glucosidase activity with IC₅₀ values of 58 ± 0.8 and 55 ± 0.5 µg/ml, respectively, whereas IC₅₀ of Acarbose as a positive control was found to be 36 ± 0.4 µg/ml in our bioassay.

WebOfScience code

https://www.webofscience.com/wos/woscc/full-record/WOS:000736810000001

Bibliographic citation

Abd El Hafez, M.S.M.; Abd El Aziz Okbah, M.; Ibrahim, H.A.H.; Abd El Rahim Hussein, A.; Abd El Moneim, N.A.; Ata, A. (2022). First report of steroid derivatives isolated from starfish Acanthaster planci with anti-bacterial, anti-cancer and anti-diabetic activities. Nat. Prod. Res. 36(21): 5545-5552. https://dx.doi.org/10.1080/14786419.2021.2021200

Topic

Marine

Is peer reviewed

true