{"refrec":{"BRefID":361133,"RR":"<b>Fullam, A.; Letunic, I.; Schmidt, T.S.B.; Ducarmon, Q.R.; Karcher, N.; Khedkar, S.; Kuhn, M.; Larralde, M.; Maistrenko, O.M.; Malfertheiner, L.; Milanese, A.; Rodrigues, J.F.M.; Sanchis-López, C.; Schudoma, C.; Szklarczyk, D.; Sunagawa, S.; Zeller, G.; Huerta-Cepas, J.; von Mering, C.; Bork, P.; Mende, D.R.</b> (2022). proGenomes3: approaching one million accurately and consistently annotated high-quality prokaryotic genomes. <i>Nucleic Acids Res. 51(D1)</i>: D760-D766. <a href=\"https://dx.doi.org/10.1093/nar/gkac1078\" target=\"_blank\">https://dx.doi.org/10.1093/nar/gkac1078</a>","BEntID":358848,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nucleic Acids Res. 51(D1)</i>: D760-D766. <a href=\"https://dx.doi.org/10.1093/nar/gkac1078\" target=\"_blank\">https://dx.doi.org/10.1093/nar/gkac1078</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Fullam, A.; Letunic, I.; Schmidt, T.S.B.; Ducarmon, Q.R.; Karcher, N.; Khedkar, S.; Kuhn, M.; Larralde, M.; Maistrenko, O.M.; Malfertheiner, L.; Milanese, A.; Rodrigues, J.F.M.; Sanchis-López, C.; Schudoma, C.; Szklarczyk, D.; Sunagawa, S.; Zeller, G.; Huerta-Cepas, J.; von Mering, C.; Bork, P.; Mende, D.R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Fullam, A. <i>et al.</i>","Englishabstract":"The interpretation of genomic, transcriptomic and other microbial ‘omics data is highly dependent on the availability of well-annotated genomes. As the number of publicly available microbial genomes continues to increase exponentially, the need for quality control and consistent annotation is becoming critical. We present proGenomes3, a database of 907 388 high-quality genomes containing 4 billion genes that passed stringent criteria and have been consistently annotated using multiple functional and taxonomic databases including mobile genetic elements and biosynthetic gene clusters. proGenomes3 encompasses 41 171 species-level clusters, defined based on universal single copy marker genes, for which pan-genomes and contextual habitat annotations are provided. 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