{"refrec":{"BRefID":361315,"RR":"<b>Zhang, S.; Van Haesebroeck, J.; Yang, Q.; Defoirdt, T.</b> (2023). Indole-3-acetic acid increases the survival of brine shrimp challenged with vibrios belonging to the Harveyi clade. <i>J. Fish Dis. 46(5)</i>: 477-486. <a href=\"https://dx.doi.org/10.1111/jfd.13759\" target=\"_blank\">https://dx.doi.org/10.1111/jfd.13759</a>","BEntID":359030,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>J. Fish Dis. 46(5)</i>: 477-486. <a href=\"https://dx.doi.org/10.1111/jfd.13759\" target=\"_blank\">https://dx.doi.org/10.1111/jfd.13759</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Zhang, S.; Van Haesebroeck, J.; Yang, Q.; Defoirdt, T.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Zhang, S. <i>et al.</i>","Englishabstract":"Vibrios belonging to the Harveyi clade (including closely related species such as <i>Vibrio campbellii</i>, <i>Vibrio harveyi</i> and <i>Vibrio parahaemolyticus</i>) are important pathogens of aquatic organisms. In this study, we investigated the use of indole-3-acetic acid to control disease caused by Harveyi clade vibrios. Indole-3-acetic acid, which can be produced by various seaweeds and microalgae, was added to the rearing water of brine shrimp larvae challenged with 12 different Harveyi clade <i>Vibrio</i> strains. Indole-3-acetic acid significantly decreased the virulence of 10 of the strains without any effect on their growth. The latter is important as it will minimize the selective pressure for resistance development. The survival rate of brine shrimp larvae increased from 1.2-fold to 4.8-fold upon treatment with 400 μM indole-3-acetic acid. Additionally, indole-3-acetic acid significantly decreased the swimming motility in 10 of the strains and biofilm formation in eight of the strains. The mRNA levels of the <i>pirA</i> and <i>pirB</i> toxin genes were decreased to 46% and 42% by indole-3-acetic acid in the AHPND-causing strain <i>V. parahaemolyticus</i> M0904. Hence, our data demonstrate that indole-3-acetic acid has the potential to be an effective virulence inhibitor to control infections in aquaculture.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Indole-3-acetic acid increases the survival of brine shrimp challenged with vibrios belonging to the Harveyi clade","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-05 01:31:29.816638","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"acute hepatopancreatic necrosis disease; biofilm; IAA; indolesignalling; motility; quorum sensing","OtherDescriptors":null,"Notes":null,"AnaPub":2023,"MonPub":null,"DateUpdate":"2023-04-06","DateCreate":"2023-02-23","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000917944300001","VABBcode":null,"OpenAcc":0,"DOI":"10.1111/jfd.13759"},"refs":null,"anarec":{"AnaID":361315,"PubliDate":2023,"Pagination":"477-486","XtraPublOfAnaID":null,"ISBN":null,"Volume":"46","Issue":"5","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":44476,"SerRR":"Journal of Fish Diseases. 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