{"refrec":{"BRefID":36212,"RR":"<b>Le Pennec, G.; Le Pennec, M.</b> (2003). Induction of glutathione-<i>S</i>-transferases in primary cultured digestive gland acini from the mollusk bivalve<i> Pecten maximus</i> (L.): application of a new cellular model in biomonitoring studies. <i>Aquat. Toxicol. 64(2)</i>: 131-142. <a href=\"https://dx.doi.org/10.1016/S0166-445X(03)00041-9\" target=\"_blank\">https://dx.doi.org/10.1016/S0166-445X(03)00041-9</a>","BEntID":36212,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 64(2)</i>: 131-142. <a href=\"https://dx.doi.org/10.1016/S0166-445X(03)00041-9\" target=\"_blank\">https://dx.doi.org/10.1016/S0166-445X(03)00041-9</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Le Pennec, G.; Le Pennec, M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Le Pennec, G.; Le Pennec, M.","Englishabstract":"In the last three decades, marine invertebrates have been used to monitor environmental health conditions and potential pollution, e.g. in the Mussel Watch Program. The whole animal or specific organs are used to determine contamination levels and disturbances. In the present study, a new in vitro cell culture model was validated for pollution monitoring. A commercial species, the scallop <i>Pecten maximus</i>, was tested for the presence and induction of phase II glutathione-S-transferase (GST) enzymes. These activities were monitored for a year, and the results were found to be consistent with those in the literature. Tributyltin, ethylmethane sulfonate and the water-soluble fraction of crude oil were assayed in, in vitro induction studies. A rapid increase of GST activities was observed within 24 h with all compounds tested, and a time- as well as a dose-response was established. 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