{"refrec":{"BRefID":362434,"RR":"<b>Lucia, G.; Giuliani, M.E.; d'Errico, G.; Booms, E.; Benedetti, M.; Di Carlo, M.; Fattorini, D.; Gorbi, S.; Regoli, F.</b> (2023). Toxicological effects of cigarette butts for marine organisms. <i>Environ. Int. 171</i>: 107733. <a href=\"https://dx.doi.org/10.1016/j.envint.2023.107733\" target=\"_blank\">https://dx.doi.org/10.1016/j.envint.2023.107733</a>","BEntID":360151,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Environ. Int. 171</i>: 107733. <a href=\"https://dx.doi.org/10.1016/j.envint.2023.107733\" target=\"_blank\">https://dx.doi.org/10.1016/j.envint.2023.107733</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Lucia, G.; Giuliani, M.E.; d'Errico, G.; Booms, E.; Benedetti, M.; Di Carlo, M.; Fattorini, D.; Gorbi, S.; Regoli, F.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Lucia, G. <i>et al.</i>","Englishabstract":"Cigarette butts (CBs), one of the most common litter items found on beaches, represent a still unexplored environmental hazard. This study aimed at a multidisciplinary characterization of their toxicological risks on marine organisms integrating chemical analyses of released compounds with a wide panel of biological responses, such as ecotoxicological bioassays on species of different trophic positions, molecular responses in an ex vivo model (Precision-Cut Tissue Slices, PCTS of mussels digestive glands), bioavailability and cellular biomarkers in mussels exposed to CBs in laboratory experiments. Trace metals, aliphatic and polycyclic aromatic hydrocarbons, nicotine and cotinine were released in artificial seawater after 24 h which determined a significant inhibition of bacterial bioluminescence, oyster embryo development and growth in different algal species. Modulation of peroxisomal proliferation and antioxidant gene expression was observed in mussels PCTS, while the in vivo exposure determined accumulation of chemicals and significant alterations of immune system, antioxidant and neurotoxic responses, peroxisomal proliferation and genotoxic damage. Using a quantitative Weight of Evidence model, the risks of CBs to the marine environment were summarized, highlighting the importance of integrating chemical analyses, batteries of ecotoxicological bioassays, molecular and cellular biomarkers to assess the impact of these hazardous materials on marine environment.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Toxicological effects of cigarette butts for marine organisms","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-21 01:33:15.224620","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Chemical mixture; Bioaccumulation; Ecotoxicological bioassays; Cellular toxicity; Quantitative weight of evidence assessment","OtherDescriptors":null,"Notes":null,"AnaPub":2023,"MonPub":null,"DateUpdate":"2023-03-24","DateCreate":"2023-03-22","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000925263500001","VABBcode":null,"OpenAcc":1,"DOI":"10.1016/j.envint.2023.107733"},"refs":null,"anarec":{"AnaID":362434,"PubliDate":2023,"Pagination":"107733","XtraPublOfAnaID":null,"ISBN":null,"Volume":"171","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42659,"SerRR":"Environment International. 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