{"refrec":{"BRefID":363503,"RR":"<b>Puspitasari, Y.E.; Tuenter, E.; Foubert, K.; Herawati, H.; Hariati, A.M.; Aulanni'am, A.; Pieters, L.; De Bruyne, T.; Hermans, N.</b> (2023). Saponin and fatty acid profiling of the sea cucumber <i>Holothuria atra</i>, α-glucosidase inhibitory activity and the identification of a novel triterpene-glycoside. <i>Nutrients 15(4)</i>: 1033. <a href=\"https://dx.doi.org/10.3390/nu15041033\" target=\"_blank\">https://dx.doi.org/10.3390/nu15041033</a>","BEntID":361221,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nutrients 15(4)</i>: 1033. <a href=\"https://dx.doi.org/10.3390/nu15041033\" target=\"_blank\">https://dx.doi.org/10.3390/nu15041033</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Puspitasari, Y.E.; Tuenter, E.; Foubert, K.; Herawati, H.; Hariati, A.M.; Aulanni'am, A.; Pieters, L.; De Bruyne, T.; Hermans, N.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Puspitasari, Y.E. <i>et al.</i>","Englishabstract":"Saponin-rich sea cucumber extracts have shown antidiabetic effects in a few reports. Although the triterpene glycosides of sea cucumbers are commonly isolated from their Cuvierian tubules, these are absent in <i>Holothuria atra</i> Jaeger. Therefore, this study intended to investigate the saponin profile in the body wall of <i>H. atra</i>, as well as to assess the α-glucosidase inhibitory activity of the <i>H. atra</i> extracts. The chemical profiling of sea cucumber extracts was conducted by UPLC-HRMS analysis. This resulted in the tentative identification of 11 compounds, 7 of which have not been reported in the <i>H. atra</i> body wall before. Additionally, two triterpene glycosides were purified and their structures were elucidated based on HRMS and NMR data: desholothurin B (1), and a novel epimer, 12-epi-desholothurin B (2). Moreover, the fatty acid profile of the <i>H. atra</i> body wall was investigated by GC-MS. It was found that the Me90 fraction of the <i>H. atra</i> body wall showed the strongest α-glucosidase inhibitory activity (IC<sub>50</sub> value 0.158 ± 0.002 mg/mL), thus making it more potent than acarbose (IC<sub>50</sub> value 2.340 ± 0.044 mg/mL).","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Saponin and fatty acid profiling of the sea cucumber <i>Holothuria atra</i>, α-glucosidase inhibitory activity and the identification of a novel triterpene-glycoside","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Holothuroidea; triterpene glycosides; Holothuria; a-glucosidase","OtherDescriptors":null,"Notes":null,"AnaPub":2023,"MonPub":null,"DateUpdate":"2023-04-12","DateCreate":"2023-04-11","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000942083800001","VABBcode":null,"OpenAcc":1,"DOI":"10.3390/nu15041033"},"refs":null,"anarec":{"AnaID":363503,"PubliDate":2023,"Pagination":"1033","XtraPublOfAnaID":null,"ISBN":null,"Volume":"15","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":275613,"SerRR":"Nutrients. 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