{"refrec":{"BRefID":364388,"RR":"<b>Kasemets, K.; Ivask, A.; Dubourguier, H.-C.; Kahru, A.</b> (2009). Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae. <i>Toxicology in vitro 23(6)</i>: 1116-1122. <a href=\"https://dx.doi.org/10.1016/j.tiv.2009.05.015\" target=\"_blank\">https://dx.doi.org/10.1016/j.tiv.2009.05.015</a>","BEntID":362108,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Toxicology in vitro 23(6)</i>: 1116-1122. <a href=\"https://dx.doi.org/10.1016/j.tiv.2009.05.015\" target=\"_blank\">https://dx.doi.org/10.1016/j.tiv.2009.05.015</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Kasemets, K.; Ivask, A.; Dubourguier, H.-C.; Kahru, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Kasemets, K. <i>et al.</i>","Englishabstract":"The aim of this study was to evaluate the toxic effect of nanosized ZnO, CuO and TiO<sub>2</sub> to <em>Saccharomyces cerevisiae</em> – a widely used unicellular eukaryotic model organisms in molecular and cell biology<em>.</em> The effect of metal oxide nanoparticles, their bulk forms and respective ionic forms were compared. The bioavailable Zn<sup>2+</sup> and Cu<sup>2+</sup> ions in the growth medium were quantified by recombinant microbial sensors.</p><p>Nano and bulk TiO<sub>2</sub> were not toxic even at 20000<!--  &nbsp;<!--  mg/l. Both, nano and bulk ZnO were of comparable toxicity (8-h EC<sub>50</sub> 121–134<!--  &nbsp;<!--  mg ZnO/l and 24-h EC<sub>50</sub> 131–158<!--  &nbsp;<!--  mg/l). The toxicity was explained by soluble Zn-ions as proved by the microbial sensor. However, nano CuO was about 60-fold more toxic than bulk CuO: 8-h EC<sub>50</sub> were 20.7 and 1297<!--  &nbsp;<!--  mg CuO/l and 24-h EC<sub>50</sub> were 13.4 and 873<!--  &nbsp;<!--  mg/l, respectively. The increase in toxicity of both CuO formulations at 24th hour of growth was due to the increased dissolution of copper ions from CuO over time. Comparison of EC<sub>50</sub> values of nano CuO, bulk CuO and Cu<sup>2+</sup> with bioavailable copper concentrations in the growth medium showed that the solubilized Cu-ions explained only about 50% of the toxicity of both, nano and bulk CuO. To our knowledge, this is the first study that evaluates the toxicity of ZnO, CuO and TiO<sub>2</sub> nanoparticles to <em>S.</em> <em>cerevisiae.</em>","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Toxicity of nanoparticles of ZnO, CuO and TiO2 to yeast Saccharomyces cerevisiae","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2009,"MonPub":null,"DateUpdate":"2023-05-17","DateCreate":"2023-05-17","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000269551500022","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.tiv.2009.05.015"},"refs":null,"anarec":{"AnaID":364388,"PubliDate":2009,"Pagination":"1116-1122","XtraPublOfAnaID":null,"ISBN":null,"Volume":"23","Issue":"6","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":218902,"SerRR":"Toxicology in vitro. 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