Document of bibliographic reference 367358
BibliographicReference record
- Type
- Bibliographic resource
- Type of document
- Journal article
- BibLvlCode
- AS
- Title
- Carotenoids from starfish Patiria pectinifera: therapeutic activity in models of inflammatory diseases
- Abstract
- The carotenoids mixture (MC) isolated from the starfish Patiria. pectinifera contains more than 50% astaxanthin, 4–6% each zeaxanthine and lutein, and less pharmacologically active components such as free fatty acids and their glycerides. Astaxanthin, the major component of MC, belongs to the xanthophyll class of carotenoids, and is well known for its antioxidant properties. In this work, in vitro and in vivo studies on the biological activity of MC were carried out. The complex was shown to exhibit anti-inflammatory, anti-allergic and cancer-preventive activity, without any toxicity at a dose of 500 mg/kg. MC effectively improves the clinical picture of the disease progressing, as well as normalizing the cytokine profile and the antioxidant defense system in the in vivo animal models of inflammatory diseases, namely: skin carcinogenesis, allergic contact dermatitis (ACD) and systemic inflammation (SI). In the skin carcinogenesis induced by 7,12-dimethylbenzanthracene, the incidence of papillomas was decreased 1.5 times; 1% MC ointment form in allergic contact dermatitis showed an 80% reduced severity of pathomorphological skin manifestations. Obtained results show that MC from starfish P. pectinifera is an effective remedy for the treatment and prevention of inflammatory processes.
- WebOfScience code
- https://www.webofscience.com/wos/woscc/full-record/WOS:001076141500001
- Bibliographic citation
- Popov, A.M.; Kozlovskaya, E.P.; Klimovich, A.A.; Rutckova, T.A.; Vakhrushev, A.I.; Hushpulian, D.M.; Gazaryan, I.G.; Makhankov, V.V.; Son, O.M.; Tekutyeva, L.A. (2023). Carotenoids from starfish Patiria pectinifera: therapeutic activity in models of inflammatory diseases. Mar. Drugs 21(9): 470. https://dx.doi.org/10.3390/md21090470
- Topic
- Marine
- Is peer reviewed
- true
- Access rights
- open access
- Is accessible for free
- true
Authors
- author
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- Name
- Aleksandr Popov
- author
-
- Name
- Emma Kozlovskaya
- author
-
- Name
- Anna Klimovich
- author
-
- Name
- Tatyana Rutckova
- author
-
- Name
- Aleksey Vakhrushev
- author
-
- Name
- Dmitry Hushpulian
- author
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- Name
- Irina Gazaryan
- author
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- Name
- Vyacheslav Makhankov
- author
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- Name
- Oksana Son
- author
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- Name
- Liudmila Tekutyeva