{"refrec":{"BRefID":381016,"RR":"<b>Liu, X.; Zheng, X.; Zhang, L.; Li, J.; Li, Y.; Huang, H.; Fan, Z.</b> (2022). Joint toxicity mechanisms of binary emerging PFAS mixture on algae (<i>Chlorella pyrenoidosa</i>) at environmental concentration. <i>J. Hazard. Mater. 437</i>: 129355. <a href=\"https://dx.doi.org/10.1016/j.jhazmat.2022.129355\" target=\"_blank\">https://dx.doi.org/10.1016/j.jhazmat.2022.129355</a>","BEntID":378757,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>J. Hazard. Mater. 437</i>: 129355. <a href=\"https://dx.doi.org/10.1016/j.jhazmat.2022.129355\" target=\"_blank\">https://dx.doi.org/10.1016/j.jhazmat.2022.129355</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":1,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Liu, X.; Zheng, X.; Zhang, L.; Li, J.; Li, Y.; Huang, H.; Fan, Z.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Liu, X. <i>et al.</i>","Englishabstract":"Since traditional Per- and polyfluoroalkyl substances (PFAS) were banned in 2009 due to their bioaccumulation, persistence and biological toxicity, the emerging PFAS have been widely used as their substitutes and entered the aquatic environment in the form of mixtures. However, the joint toxicity mechanisms of these emerging PFAS mixtures to aquatic organisms remain largely unknown. Then, based on the testing of growth inhibition, cytotoxicity, photosynthesis and <a href=\"https://www.sciencedirect.com/topics/earth-and-planetary-sciences/oxidative-stress\">oxidative stress</a>, and the toxicity mechanism of PFAS mixture (Perfluorobutane <a href=\"https://www.sciencedirect.com/topics/earth-and-planetary-sciences/sulfonate\">sulfonate</a> and Perfluorobutane sulfonamide) to algae was explored using the Gene set enrichment analysis (GSEA). The results revealed that all three emerging PFAS treatments had a certain growth inhibitory effect on <a href=\"https://www.sciencedirect.com/topics/earth-and-planetary-sciences/chlorella\"><i>Chlorella</i></a><i> pyrenoidosa</i> (<i>C. pyrenoidosa</i>), but the toxicity of PFAS mixture was stronger than that of individual PFAS and showed a significant synergistic effect at environmental concentration. The joint toxicity mechanisms of binary PFAS mixture to <i>C. pyrenoidosa</i> were related to the damage of photosynthetic system, obstruction of <a href=\"https://www.sciencedirect.com/topics/earth-and-planetary-sciences/reactive-oxygen-species\">ROS</a> metabolism, and inhibition of DNA replication. Our findings are conductive to adding knowledge in understanding the joint toxicity mechanisms and provide a basis for assessing the environmental risk of emerging PFAS.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Joint toxicity mechanisms of binary emerging PFAS mixture on algae (<i>Chlorella pyrenoidosa</i>) at environmental concentration","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-11 01:33:09.293052","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Inhibition effect; Synergetic effect; Transcriptome; Biological pathway","OtherDescriptors":null,"Notes":null,"AnaPub":2022,"MonPub":null,"DateUpdate":"2024-01-22","DateCreate":"2024-01-22","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000815942200001","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.jhazmat.2022.129355"},"refs":null,"anarec":{"AnaID":381016,"PubliDate":2022,"Pagination":"129355","XtraPublOfAnaID":null,"ISBN":null,"Volume":"437","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43064,"SerRR":"Journal of hazardous materials. 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