{"refrec":{"BRefID":381433,"RR":"<b>Born-Torrijos, A.; van Beest, G.S.; Merella, P.; Garippa, G.; Raga, J.A.; Montero, F.E.</b> (2023). Mapping a brain parasite: occurrence and spatial distribution in fish encephalon. <i>IJP 21</i>: 22-32. <a href=\"https://dx.doi.org/10.1016/j.ijppaw.2023.03.004\" target=\"_blank\">https://dx.doi.org/10.1016/j.ijppaw.2023.03.004</a>","BEntID":379174,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>IJP 21</i>: 22-32. <a href=\"https://dx.doi.org/10.1016/j.ijppaw.2023.03.004\" target=\"_blank\">https://dx.doi.org/10.1016/j.ijppaw.2023.03.004</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Born-Torrijos, A.; van Beest, G.S.; Merella, P.; Garippa, G.; Raga, J.A.; Montero, F.E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Born-Torrijos, A. <i>et al.</i>","Englishabstract":"<span style=\"color:rgb(31,31,31);\">Parasites, especially brain-encysting trematodes, can have an impact on host behaviour, facilitating the transmission to next host and completion of the life cycle, but insufficient research has been done on whether specific </span><a href=\"https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/protocerebrum\"><span style=\"color:rgb(31,31,31);\">brain</span></a><span style=\"color:rgb(31,31,31);\"> regions are targeted. Using </span><i>Cardiocephaloides longicollis</i><span style=\"color:rgb(31,31,31);\"> as a laboratory model, the precise distribution of </span><a href=\"https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/metacercariae\"><span style=\"color:rgb(31,31,31);\">metacercariae</span></a><span style=\"color:rgb(31,31,31);\"> in experimentally-infected, wild and farmed fish was mapped. The brain regions targeted by this parasite were explored, also from a histologic perspective, and potential pathogenic effects were evaluated. Experimental infections allowed to reproduce the natural infection intensity of </span><i>C. longicollis</i><span style=\"color:rgb(31,31,31);\">, with four times higher infection intensity at the higher dose (150 </span><i>vs</i><span style=\"color:rgb(31,31,31);\"> 50 cercariae). The observed metacercarial distribution, similar among all fish groups, may reflect a trematode species-specific pattern: metacercariae occur with highest density in the </span><a href=\"https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/optic-lobe\"><span style=\"color:rgb(31,31,31);\">optic lobe</span></a><span style=\"color:rgb(31,31,31);\"> area (primarily infecting the periventricular gray zone of optic tectum) and the </span><a href=\"https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/medulla-oblongata\"><span style=\"color:rgb(31,31,31);\">medulla oblongata</span></a><span style=\"color:rgb(31,31,31);\">, whereas other areas such as the </span><a href=\"https://www.sciencedirect.com/topics/immunology-and-microbiology/olfactory-lobe\"><span style=\"color:rgb(31,31,31);\">olfactory lobes</span></a><span style=\"color:rgb(31,31,31);\"> and cerebellar lobes may be occupied when the more frequently invaded parts of the brain were crowded. Mono- and multicysts (i.e. formed either with a single metacercaria, or with 2–25 metacercariae encapsulated together) may be formed depending on the aggregation and timing of metacercariae arrival, with minor host inflammatory response. Larvae of </span><i>C. longicollis</i><span style=\"color:rgb(31,31,31);\"> colonizing specific brain areas may have an effect on the functions associated with these areas, which are generally related to sensory and motor functions, but are also related to other host fitness traits such as school maintenance or recognition of predators. The detailed information on the extent and distribution of </span><i>C. longicollis</i><span style=\"color:rgb(31,31,31);\"> in fish encephalon sets the ground to understand the effects of brain parasites on fish, but further investigation to establish if </span><i>C. longicollis</i><span style=\"color:rgb(31,31,31);\">, through purely mechanical damage (e.g., occupation, pressure and displacement), has an actual impact on host behaviour remains to be tested under controlled experimental conditions.</span>","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Mapping a brain parasite: occurrence and spatial distribution in fish encephalon","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-23 01:33:28.072845","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"<p style=\"margin-left:0px;\">Microhabitat selection; Trematoda; Histology; Brain-encysting; <i>Cardiocephaloides longicollis</i>","OtherDescriptors":null,"Notes":null,"AnaPub":2023,"MonPub":null,"DateUpdate":"2024-02-05","DateCreate":"2024-02-05","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:001122350800001","VABBcode":null,"OpenAcc":1,"DOI":"10.1016/j.ijppaw.2023.03.004"},"refs":null,"anarec":{"AnaID":381433,"PubliDate":2023,"Pagination":"22-32","XtraPublOfAnaID":null,"ISBN":null,"Volume":"21","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":260431,"SerRR":"International Journal for Parasitology: Parasites and Wildlife. Australian Society for Parasitology.  e-ISSN 2213-2244","StandardTitleSer":"International Journal for Parasitology: Parasites and Wildlife","ISSN":null,"AbbrevSer":"IJP","StandardTitleMon":null,"StartPage":22,"Pages":11,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Born-Torrijos","Firstname":"Ana","Initials":"A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":379174,"AutID":470048,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"van Beest","Firstname":"Gabrielle","Initials":"G.S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":379174,"AutID":470049,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Merella","Firstname":"Paolo","Initials":"P.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":379174,"AutID":23423,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Garippa","Firstname":"Giovanni","Initials":"G.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":379174,"AutID":23424,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Raga","Firstname":"Juan Antonio","Initials":"J.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":379174,"AutID":157546,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":9608,"InsID":null},{"AutName":"Montero","Firstname":"Francisco Esteban","Initials":"F.E.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":379174,"AutID":404525,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":379174,"BEntPrivate":null,"availability":[{"BInstID":395781,"LibID":2779,"BRefID":381433,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"395781","RFID":null,"PaidValue":null,"Medium":"Server","Description":null,"Acronym":null,"Library":"NIOZ","DutchTerm":null,"URL":null,"ClassifID":260,"Classification":"NIOZ Open Repository","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":null,"LoggedInReq":null,"Disclaimer":"Disclaimer_NIOZ","DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":397,"FileFormID":6,"LendableFlag":null,"PublicFlag":1,"orderLib":"NIOZ","Notes":null,"AccConID":26,"AccessConstraint":"Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)","LicURL":"https://creativecommons.org/licenses/by-nc-nd/4.0"}],"litstyles":null,"thespers":null,"arch2discl":805,"SERpubls":[{"PublName":"Australian Society for Parasitology","City":null}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":{"805":{"SpName":"Koninklijk Nederlands Instituut voor Onderzoek der Zee","SpColID":805,"ParSpColID":null,"TopParID":null,"ShortName":"NIOZ","URLLocation":"https://www.vliz.be/imis/nioz/imis.php?refid=","LibID":2779,"OpenRepoFlag":1,"SpTypID":1,"TopParIDNotWebsite":null,"SpColPath":"NIOZ"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":379174,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":379174,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1016/j.ijppaw.2023.03.004","externalID":"10.1016/j.ijppaw.2023.03.004","URLTypeCode":"DOI","URLID":127691,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"daan.van.loon@nioz.nl","newSesDate":{"date":"2024-02-05 12:02:22.650000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"daan.van.loon@nioz.nl","updSesDate":{"date":"2024-02-05 12:02:22.650000","timezone_type":3,"timezone":"Europe/Brussels"}}}