{"refrec":{"BRefID":381440,"RR":"<b>Donoghue, P.C.J.; Kay, C.; Spang, A.; Szöllosi, G.J.; Nenarokova, A.; Moody, E.R.R.; Pisani, D.; Williams, T.A.</b> (2023). Defining eukaryotes to dissect eukaryogenesis. <i>Curr. Biol. 33(17)</i>: R919-R929. <a href=\"https://dx.doi.org/10.1016/j.cub.2023.07.048\" target=\"_blank\">https://dx.doi.org/10.1016/j.cub.2023.07.048</a>","BEntID":379181,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Curr. Biol. 33(17)</i>: R919-R929. <a href=\"https://dx.doi.org/10.1016/j.cub.2023.07.048\" target=\"_blank\">https://dx.doi.org/10.1016/j.cub.2023.07.048</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Donoghue, P.C.J.; Kay, C.; Spang, A.; Szöllosi, G.J.; Nenarokova, A.; Moody, E.R.R.; Pisani, D.; Williams, T.A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Donoghue, P.C.J. <i>et al.</i>","Englishabstract":"<span style=\"color:rgb(31,31,31);\">The origin of eukaryotes is among the most contentious debates in evolutionary biology, attracting multiple seemingly incompatible theories seeking to explain the sequence in which eukaryotic characteristics were acquired. Much of the controversy arises from differing views on the defining characteristics of eukaryotes. We argue that eukaryotes should be defined phylogenetically, and that doing so clarifies where competing hypotheses of eukaryogenesis agree and how we may test among aspects of disagreement. Some hypotheses make predictions about the </span><a href=\"https://www.sciencedirect.com/topics/neuroscience/phylogenetics\"><span style=\"color:rgb(31,31,31);\">phylogenetic</span></a><span style=\"color:rgb(31,31,31);\"> origins of eukaryotic genes and are distinguishable on that basis. However, other hypotheses differ only in the order of key evolutionary steps, like mitochondrial </span><a href=\"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/endosymbiosis\"><span style=\"color:rgb(31,31,31);\">endosymbiosis</span></a><span style=\"color:rgb(31,31,31);\"> and nuclear assembly, which cannot currently be distinguished phylogenetically. Stages within eukaryogenesis may be made identifiable through the absolute dating of </span>gene duplicates<span style=\"color:rgb(31,31,31);\"> that map to eukaryotic traits, such as in genes of host or mitochondrial origin that duplicated and diverged functionally prior to emergence of the last eukaryotic common ancestor. In this way, it may finally be possible to distinguish heat from light in the debate over eukaryogenesis.</span>","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Defining eukaryotes to dissect eukaryogenesis","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-18 01:32:42.492213","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2023,"MonPub":null,"DateUpdate":"2024-02-05","DateCreate":"2024-02-05","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:001106670500001","VABBcode":null,"OpenAcc":1,"DOI":"10.1016/j.cub.2023.07.048"},"refs":null,"anarec":{"AnaID":381440,"PubliDate":2023,"Pagination":"R919-R929","XtraPublOfAnaID":null,"ISBN":null,"Volume":"33","Issue":"17","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":72005,"SerRR":"Current Biology. 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