{"refrec":{"BRefID":382814,"RR":"<b>Bruzos, A.L.; Santamarina, M.; Garcia-Souto, D.; Diaz, S.; Rocha, S.; Zamora, J.; Lee, Y.A.; Vina-Feas, A.; Quail, M.A.; Otero, I.; Pequeno-Valtierra, A.; Temes, J.; Rodriguez-Castro, J.; Aramburu, L.; Vidal-Capon, A.; Villanueva, A.; Costas, D.; Rodriguez, R.; Prieto, T.; Tomas, L.; Alvarino, P.; Alonso, J.; Cao, A.S.C.; Iglesias, D.; Carballal, M.J.; Amaral, A.M.; Balseiro, P.; Calado, R.; El Khalfi, B.; Izagirre, U.; de Montaudouin, X.; Pade, N.G.; Probert, I.; Ricardo, F.; Ruiz, P.; Skazina, M.; Smolarz, K.; Pasantes, J.J.; Villalba, A.; Ning, Z.M.; Ju, Y.S.; Posada, D.; Demeulemeester, J.; Baez-Ortega, A.; Tubio, J.M.C.</b> (2023). Somatic evolution of marine transmissible leukemias in the common cockle, <i>Cerastoderma edule</i>. <i>Nature Cancer 4(11)</i>: 1575-1591. <a href=\"https://dx.doi.org/10.1038/s43018-023-00641-9\" target=\"_blank\">https://dx.doi.org/10.1038/s43018-023-00641-9</a>","BEntID":380556,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Nature Cancer 4(11)</i>: 1575-1591. <a href=\"https://dx.doi.org/10.1038/s43018-023-00641-9\" target=\"_blank\">https://dx.doi.org/10.1038/s43018-023-00641-9</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Bruzos, A.L.; Santamarina, M.; Garcia-Souto, D.; Diaz, S.; Rocha, S.; Zamora, J.; Lee, Y.A.; Vina-Feas, A.; Quail, M.A.; Otero, I.; Pequeno-Valtierra, A.; Temes, J.; Rodriguez-Castro, J.; Aramburu, L.; Vidal-Capon, A.; Villanueva, A.; Costas, D.; Rodriguez, R.; Prieto, T.; Tomas, L.; Alvarino, P.; Alonso, J.; Cao, A.S.C.; Iglesias, D.; Carballal, M.J.; Amaral, A.M.; Balseiro, P.; Calado, R.; El Khalfi, B.; Izagirre, U.; de Montaudouin, X.; Pade, N.G.; Probert, I.; Ricardo, F.; Ruiz, P.; Skazina, M.; Smolarz, K.; Pasantes, J.J.; Villalba, A.; Ning, Z.M.; Ju, Y.S.; Posada, D.; Demeulemeester, J.; Baez-Ortega, A.; Tubio, J.M.C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Bruzos, A.L. <i>et al.</i>","Englishabstract":"Transmissible cancers are malignant cell lineages that spread clonally between individuals. Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like disease in marine bivalves. This is the case of BTN lineages affecting the common cockle, <i>Cerastoderma edule</i>, which inhabits the Atlantic coasts of Europe and northwest Africa. To investigate the evolution of cockle BTN, we collected 6,854 cockles, diagnosed 390 BTN tumors, generated a reference genome and assessed genomic variation across 61 tumors. Our analyses confirmed the existence of two BTN lineages with hemocytic origins. Mitochondrial variation revealed mitochondrial capture and host co-infection events. Mutational analyses identified lineage-specific signatures, one of which likely reflects DNA alkylation. Cytogenetic and copy number analyses uncovered pervasive genomic instability, with whole-genome duplication, oncogene amplification and alkylation-repair suppression as likely drivers. Satellite DNA distributions suggested ancient clonal origins. Our study illuminates long-term cancer evolution under the sea and reveals tolerance of extreme instability in neoplastic genomes.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Somatic evolution of marine transmissible leukemias in the common cockle, <i>Cerastoderma edule</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2023,"MonPub":null,"DateUpdate":"2024-03-18","DateCreate":"2024-02-16","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:001085355800004","VABBcode":null,"OpenAcc":0,"DOI":"10.1038/s43018-023-00641-9"},"refs":null,"anarec":{"AnaID":382814,"PubliDate":2023,"Pagination":"1575-1591","XtraPublOfAnaID":null,"ISBN":null,"Volume":"4","Issue":"11","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":377436,"SerRR":"Nature Cancer. 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