{"refrec":{"BRefID":382877,"RR":"<b>Cooreman, K.; De Spiegeleer, B.; Van Poucke, C.; Vanavermaete, D.; Delbare, D.; Wynendaele, E.; De Witte, B.</b> (2023). Emerging pharmaceutical therapies of Ascidian-derived natural products and derivatives. <i>Environ. Toxicol. Pharmacol. 102</i>: 104254. <a href=\"https://dx.doi.org/10.1016/j.etap.2023.104254\" target=\"_blank\">https://dx.doi.org/10.1016/j.etap.2023.104254</a>","BEntID":380619,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Environ. Toxicol. Pharmacol. 102</i>: 104254. <a href=\"https://dx.doi.org/10.1016/j.etap.2023.104254\" target=\"_blank\">https://dx.doi.org/10.1016/j.etap.2023.104254</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Cooreman, K.; De Spiegeleer, B.; Van Poucke, C.; Vanavermaete, D.; Delbare, D.; Wynendaele, E.; De Witte, B.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Cooreman, K. <i>et al.</i>","Englishabstract":"In a growing multidrug-resistant environment, the identification of potential new drug candidates with an acceptable safety profile is a substantial crux in pharmaceutical discovery. This review discusses several aspects and properties of approved marine natural products derived from ascidian sources (phylum Chordata, subphylum Tunicata) and/or their deduced analogues including their biosynthetic origin, (bio)chemical preclinical assessments and known efficacy-safety profiles, clinical status in trials, but also translational developments, opportunities and final conclusions. The review also describes the preclinical assessments of a large number of other ascidian compounds that have not been involved in clinical trials yet. Finally, the emerging research on the connectivity of the ascidian hosts and their independent or obligate symbiotic guests is discussed. 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