{"refrec":{"BRefID":38299,"RR":"<b>Madsen, L.L.; Korsgaard, B.; Bjerregaard, P.</b> (2003). Estrogenic effects in flounder <i>Platichthys flesus</i> orally exposed to 4-tert-octylphenol. <i>Aquat. Toxicol. 64(4)</i>: 393-405. <a href=\"https://dx.doi.org/10.1016/S0166-445X(03)00106-1\" target=\"_blank\">https://dx.doi.org/10.1016/S0166-445X(03)00106-1</a>","BEntID":38299,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 64(4)</i>: 393-405. <a href=\"https://dx.doi.org/10.1016/S0166-445X(03)00106-1\" target=\"_blank\">https://dx.doi.org/10.1016/S0166-445X(03)00106-1</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Madsen, L.L.; Korsgaard, B.; Bjerregaard, P.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Madsen, L.L.; Korsgaard, B.; Bjerregaard, P.","Englishabstract":"The estrogenic effect of dietary 4-tert-octylphenol in the flounder <i>Platichthys flesus</i> was investigated in the laboratory. In the first experiment male flounders were fed doses of 10, 50 and 100 mg 4-tert-octylphenol kg<sup>-1</sup> BW or 0.05 mg 17β-estradiol kg<sup>-1</sup> BW every second day for 10 days. Increases in the plasma content of vitellogenin were observed on day 6 by the first sampling in all treated groups. An effect of octylphenol on the size of the liver and testis was only seen in one of the exposed group (50 mg 4-tert-octylphenol kg<sup>-1</sup> BW). An increase in the concentration of 4-tert-octylphenol was found in both liver and muscle tissues of all 4-tert-octylphenol treated fish. The concentration of 4-tert-octylphenol (ng g<sup>-1</sup>+ WW) in liver tissue was four to five times greater than the concentration in muscle tissue. Only about 8% of the 4-tert-octylphenol administered to the group receiving 50 mg 4-tert-octylphenol kg<sup>-1</sup> BW was retained in the liver and the muscles at the end of the experiment. In the second experiment male flounders were exposed to a low dose range of 4-tert-octylphenol (1 to 25 mg 4-tert-octylphenol kg<sup>-1</sup> BW) in order to establish the dose-response relationship of 4-tert-octylphenol when applied by feeding to flounder. Vitellogenin induction (LOED) occurred at 10 and 5 mg 4-tert-octylphenol kg<sup>-1</sup> BW after, respectively, 6 and 11 days of exposure. Based on a logistic regression analysis the effect dose (ED<sub>50</sub> could be determined as 8.2 and 5.6 mg 4-tert-octylphenol kg<sup>-1</sup> BW on day 6 and 11, respectively. 4-tert-octylphenol accumulated in liver, muscle and testis tissue, and a significant accumulation in liver was found at 2.5 mg 4-tert-octylphenol kg<sup>-1</sup> BW and in muscle and testis at 5 mg 4-tert-octylphenol kg<sup>-</sup>1 BW. Finally, a positive correlation between the plasma vitellogenin concentration and the liver tissue concentration of 4-tert-octylphenol was established as well as a positive correlation between the content of 4-tert-octylphenol in liver and muscle/testis tissue.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Estrogenic effects in flounder <i>Platichthys flesus</i> orally exposed to 4-tert-octylphenol","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-14 01:31:06.906066","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":"4-tert-Octylphenol; Vitellogenin; Dietary exposure; Estrogenic effect","Notes":null,"AnaPub":2003,"MonPub":null,"DateUpdate":"2019-08-09","DateCreate":"2003-08-11","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000184584800003","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/S0166-445X(03)00106-1"},"refs":null,"anarec":{"AnaID":38299,"PubliDate":2003,"Pagination":"393-405","XtraPublOfAnaID":null,"ISBN":null,"Volume":"64","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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