{"refrec":{"BRefID":38626,"RR":"<b>Porte, C.; Escartín, E.; García de la Parra, L.M.; Biosca, X.; Albaiges, J.</b> (2002). Assessment of coastal pollution by combined determination of chemical and biochemical markers in <i>Mullus barbatus</i>. <i>Mar. Ecol. Prog. Ser. 235</i>: 205-216. <a href=\"https://dx.doi.org/10.3354/meps235205\" target=\"_blank\">https://dx.doi.org/10.3354/meps235205</a>","BEntID":38626,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Mar. Ecol. Prog. Ser. 235</i>: 205-216. <a href=\"https://dx.doi.org/10.3354/meps235205\" target=\"_blank\">https://dx.doi.org/10.3354/meps235205</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Porte, C.; Escartín, E.; García de la Parra, L.M.; Biosca, X.; Albaiges, J.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Porte, C. <i>et al.</i>","Englishabstract":"Muscle concentrations of organochlorinated compounds as well as biliary levels of polycyclic aromatic hydrocarbon (PAH) metabolites were determined in red mullet Mullus barbatus as a sentinel species for assessing the pollution along the western Mediterranean coast. A battery of biochemical markers—biotransformation and antioxidant enzymes—were also measured in liver sub-cellular fractions to assess exposure to pollutants. Among them, 7-ethoxyresorufin O-deethylase  (EROD) activity, as well as 7-penthoxyresorufin O-deethylase (PROD) activity and cytochrome P450 1A (CYP1A) content evidenced strong differences among sampling sites, and a good correlation with the amount of PCBs bioaccumulated by fish. No clear pollution-related response was observed for cytosolic glutathione S-transferase, whereas uridine-diphosphate UDP-glucuronyltransferase  (UDPGT) was elevated in fish from polluted sites. Antioxidant enzymes—superoxide dismutase  (SOD), catalase and glutathione peroxidase (GPX)—were used to assess oxidative stress. 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