{"refrec":{"BRefID":391044,"RR":"<b>Brooks, S.; Martins, S.; De Witte, B.; Bellas, J.; Hylland, K.; Mauffret, A.; Sturve, J.; Temperley, E.; Barber, J.; Lipizer, M.; Tsabaris, C.; Yakushev, E.; Lillicrap, A.</b> (2024). Contaminants of emerging concern in the marine environment: an integrated effects assessment approach (CONTRAST), <b><i>in</i></b>: <i>EGU General Assembly 2024. Vienna, Austria & Online, 14-19 April 2024.</i> pp. EGU24-21844. <a href=\"https://dx.doi.org/10.5194/egusphere-egu24-21844\" target=\"_blank\">https://dx.doi.org/10.5194/egusphere-egu24-21844</a>","BEntID":388791,"PublicFlag":1,"CheckedFlag":0,"wosflag":0,"vabbflag":0,"RefStringPartII":", <b><i>in</i></b>: <i>EGU General Assembly 2024. Vienna, Austria & Online, 14-19 April 2024.</i> pp. EGU24-21844. <a href=\"https://dx.doi.org/10.5194/egusphere-egu24-21844\" target=\"_blank\">https://dx.doi.org/10.5194/egusphere-egu24-21844</a>","DocTypID":17,"DocType":"Book chapters","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Brooks, S.; Martins, S.; De Witte, B.; Bellas, J.; Hylland, K.; Mauffret, A.; Sturve, J.; Temperley, E.; Barber, J.; Lipizer, M.; Tsabaris, C.; Yakushev, E.; Lillicrap, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Brooks, S. <i>et al.</i>","Englishabstract":"<span style=\"background-color:rgb(255,255,255);color:rgba(50,50,50,0.9);\">The Horizon Europe project, CONTRAST, will develop an integrated assessment and effect-based monitoring framework (IAF) to measure the impacts of contaminants of emerging concern (CECs) on the marine environment, which will contribute to the assessment of Good Environmental/ Ecological Status for application in EU policy (MSFD/WFD). The IAF will involve chemical measurements together with biological effects endpoints optimised to detect the presence and effect of CECs in the marine environment. Chemical prioritisation schemes will identify the CECs that pose the greatest threat to marine life and select which CECs to target in the laboratory experiments, where the effects on organisms and biodiversity will be assessed. </span><i>In silico</i><span style=\"background-color:rgb(255,255,255);color:rgba(50,50,50,0.9);\">, </span><i>in vitro</i><span style=\"background-color:rgb(255,255,255);color:rgba(50,50,50,0.9);\"> and </span><i>in vivo</i><span style=\"background-color:rgb(255,255,255);color:rgba(50,50,50,0.9);\"> bioassays will be used to determine the mechanisms of toxicity of selected CECs. Providing information on how CECs interact with organisms at environmentally relevant concentrations and which biological effects tools should be used in the IAF to cover the range of toxicity mechanisms that CECs produce. A series of European-wide case studies will be used to test the suitability of the IAF to measure the effects of chemicals including CECs on indicator species and biodiversity and to model fate of CECs in marine environment. 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