{"refrec":{"BRefID":391547,"RR":"<b>Styfhals, R.; Zolotarov, G.; Hulselmans, G.; Spanier, K.I.; Poovathingal, S.; Elagoz, A.M.; De Winter, S.; Deryckere, A.; Rajewsky, N.; Ponte, G.; Fiorito, G.; Aerts, S.; Seuntjens, E.</b> (2022). Cell type diversity in a developing octopus brain. <i>Nature Comm. 13(1)</i>: 7392. <a href=\"https://dx.doi.org/10.1038/s41467-022-35198-1\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-022-35198-1</a>","BEntID":389294,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Comm. 13(1)</i>: 7392. <a href=\"https://dx.doi.org/10.1038/s41467-022-35198-1\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-022-35198-1</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Styfhals, R.; Zolotarov, G.; Hulselmans, G.; Spanier, K.I.; Poovathingal, S.; Elagoz, A.M.; De Winter, S.; Deryckere, A.; Rajewsky, N.; Ponte, G.; Fiorito, G.; Aerts, S.; Seuntjens, E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Styfhals, R. <i>et al.</i>","Englishabstract":"Octopuses are mollusks that have evolved intricate neural systems comparable with vertebrates in terms of cell number, complexity and size. The brain cell types that control their sophisticated behavioral repertoire are still unknown. Here, we profile the&nbsp;cell diversity of the paralarval <i>Octopus vulgaris</i> brain to build a cell type atlas that comprises mostly neural cells, but also multiple glial subtypes, endothelial cells and fibroblasts. We spatially map cell types to the vertical, subesophageal and optic lobes. Investigation of cell type conservation reveals a shared gene signature between glial cells of mouse, fly and octopus. Genes related to learning and memory are enriched in vertical lobe cells, which show molecular similarities with Kenyon cells in <i>Drosophila</i>. We construct a cell type taxonomy revealing transcriptionally related cell types, which tend to appear in the same brain region. 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