{"refrec":{"BRefID":393662,"RR":"<b>Ding, S.; Hamm, J.N.; Bale, N.J.; Sinninghe Damsté, J.S.; Spang, A.</b> (2024). Selective lipid recruitment by an archaeal DPANN symbiont from its host. <i>Nature Comm. 15(1)</i>: 3405. <a href=\"https://dx.doi.org/10.1038/s41467-024-47750-2\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-024-47750-2</a>","BEntID":391450,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Nature Comm. 15(1)</i>: 3405. <a href=\"https://dx.doi.org/10.1038/s41467-024-47750-2\" target=\"_blank\">https://dx.doi.org/10.1038/s41467-024-47750-2</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Ding, S.; Hamm, J.N.; Bale, N.J.; Sinninghe Damsté, J.S.; Spang, A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Ding, S. <i>et al.</i>","Englishabstract":"<span style=\"background-color:rgb(255,255,255);color:rgb(34,34,34);\">The symbiont </span><i>Ca</i><span style=\"background-color:rgb(255,255,255);color:rgb(34,34,34);\">. Nanohaloarchaeum antarcticus is obligately dependent on its host </span><i>Halorubrum lacusprofundi</i><span style=\"background-color:rgb(255,255,255);color:rgb(34,34,34);\"> for lipids and other metabolites due to its lack of certain biosynthetic genes. However, it remains unclear which specific lipids or metabolites are acquired from its host, and how the host responds to infection. Here, we explored the lipidome dynamics of the </span><i>Ca</i><span style=\"background-color:rgb(255,255,255);color:rgb(34,34,34);\">. Nha. antarcticus – </span><i>Hrr. lacusprofundi</i><span style=\"background-color:rgb(255,255,255);color:rgb(34,34,34);\"> symbiotic relationship during co-cultivation. By using a comprehensive untargeted lipidomic methodology, our study reveals that </span><i>Ca</i><span style=\"background-color:rgb(255,255,255);color:rgb(34,34,34);\">. Nha. antarcticus selectively recruits 110 lipid species from its host, i.e., nearly two-thirds of the total number of host lipids. Lipid profiles of co-cultures displayed shifts in abundances of bacterioruberins and menaquinones and changes in degree of bilayer-forming glycerolipid unsaturation. This likely results in increased membrane fluidity and improved resistance to membrane disruptions, consistent with compensation for higher metabolic load and mechanical stress on host membranes when in contact with </span><i>Ca</i><span style=\"background-color:rgb(255,255,255);color:rgb(34,34,34);\">. Nha. antarcticus cells. Notably, our findings differ from previous observations of other DPANN symbiont-host systems, where no differences in lipidome composition were reported. Altogether, our work emphasizes the strength of employing untargeted lipidomics approaches to provide details into the dynamics underlying a DPANN symbiont-host system.</span>","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Selective lipid recruitment by an archaeal DPANN symbiont from its host","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-10 01:32:58.777405","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2024,"MonPub":null,"DateUpdate":"2024-07-30","DateCreate":"2024-07-30","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1,"DOI":"10.1038/s41467-024-47750-2"},"refs":null,"anarec":{"AnaID":393662,"PubliDate":2024,"Pagination":"3405","XtraPublOfAnaID":null,"ISBN":null,"Volume":"15","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":198717,"SerRR":"Nature Communications. Nature Publishing Group: London.  ISSN 2041-1723; e-ISSN 2041-1723","StandardTitleSer":"Nature Communications","ISSN":"2041-1723","AbbrevSer":"Nature Comm.","StandardTitleMon":null,"StartPage":3405,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Ding","Firstname":"Su","Initials":"S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":391450,"AutID":462733,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"MMB","InsFSN":"Koninklijk Nederlands Instituut voor Onderzoek der Zee; Marine Microbiology and Biogeochemistry","ORCID":"0000-0001-6213-3982","PersID":40533,"InsID":13655},{"AutName":"Hamm","Firstname":"Joshua","Initials":"J.N.","Affiliation":"MMB","Discriminator":null,"CorporateFlag":0,"BEntID":391450,"AutID":545565,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Bale","Firstname":"Nicole","Initials":"N.J.","Affiliation":"MMB","Discriminator":null,"CorporateFlag":0,"BEntID":391450,"AutID":211687,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":"MMB","InsFSN":"Koninklijk Nederlands Instituut voor Onderzoek der Zee; 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