Document of bibliographic reference 396868
BibliographicReference record
- Type
- Bibliographic resource
- Type of document
- Journal article
- BibLvlCode
- AS
- Title
- New Discorhabdin D Analogues from Latrunculia spp. Sponges
- Abstract
- Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3–6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.
- Bibliographic citation
- Orfanoudaki, M.; Dalilian, M.; Du, L.; Chau, C.H.; Figg, W.D.; O’Keefe, B.R.; Grkovic, T. (2024). New Discorhabdin D Analogues from Latrunculia spp. Sponges. J. Nat. Prod. 2024. https://dx.doi.org/10.1021/acs.jnatprod.4c01036
- Topic
- Marine
- Is peer reviewed
- true
Authors
- author
-
- Name
- Maria Orfanoudaki
- author
-
- Name
- Masoumeh Dalilian
- author
-
- Name
- Ling Du
- author
-
- Name
- Cindy Chau
- author
-
- Name
- William Figg
- author
-
- Name
- Barry O’Keefe
- author
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- Name
- Tanja Grkovic