{"refrec":{"BRefID":405519,"RR":"<b>Rodriguez Jimenez, A.; Breine, A.; Whiteway, C.; Dechamps, E.; George, I.F.; Van der Henst, C.</b> (2024). Bactericidal effect of bacteria isolated from the marine sponges <i>Hymeniacidon perlevis</i> and <i>Halichondria panicea</i> against carbapenem-resistant <i>Acinetobacter baumannii</i>. <i>Letters in Applied Microbiology 77(5)</i>: ovae035. <a href=\"https://dx.doi.org/10.1093/lambio/ovae035\" target=\"_blank\">https://dx.doi.org/10.1093/lambio/ovae035</a>","BEntID":403314,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Letters in Applied Microbiology 77(5)</i>: ovae035. <a href=\"https://dx.doi.org/10.1093/lambio/ovae035\" target=\"_blank\">https://dx.doi.org/10.1093/lambio/ovae035</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Rodriguez Jimenez, A.; Breine, A.; Whiteway, C.; Dechamps, E.; George, I.F.; Van der Henst, C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Rodriguez Jimenez, A. <i>et al.</i>","Englishabstract":"In this study, we evaluated the antimicrobial activity of bacteria isolated from the marine sponges Hymeniacidon perlevis and Halichondria panicea against seven Acinetobacter baumannii strains, the majority of which were clinically relevant carbapenem-resistant A. baumannii strains. We observed the inhibitory activity of 18 (out of 114) sponge-isolated bacterial strains against all A. baumannii strains using medium-throughput solid agar overlay assays. These inhibitory strains belonged to the genera Lactococcus, Pseudomonas, and Vagococcus. In addition, this antimicrobial activity was validated through a liquid co-cultivation challenge using an inhibitory strain of each genus and a green fluorescent protein-tagged A. baumannii strain. Fluorescence measurements indicated that the growth of A. baumannii was inhibited by the sponge isolates. In addition, the inability of A. baumannii to grow after spreading the co-cultures on solid medium allowed us to characterize the activity of the sponge isolates as bactericidal. In conclusion, this study demonstrates that marine sponges are a reservoir of bacteria that deserves to be tapped for antibiotic discovery against A. baumannii.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Bactericidal effect of bacteria isolated from the marine sponges <i>Hymeniacidon perlevis</i> and <i>Halichondria panicea</i> against carbapenem-resistant <i>Acinetobacter baumannii</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-09-25 01:36:50.712317","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"antimicrobial resistance, marine microbiology, lactic acid bacteria, novel antimicrobials","OtherDescriptors":null,"Notes":null,"AnaPub":2024,"MonPub":null,"DateUpdate":"2025-09-18","DateCreate":"2025-01-22","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:001251116600001","VABBcode":null,"OpenAcc":0,"DOI":"10.1093/lambio/ovae035"},"refs":null,"anarec":{"AnaID":405519,"PubliDate":2024,"Pagination":"ovae035","XtraPublOfAnaID":null,"ISBN":null,"Volume":"77","Issue":"5","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":108045,"SerRR":"Letters in Applied Microbiology. 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