{"refrec":{"BRefID":406068,"RR":"<b>Cruz-Laufer, A.J.; Vanhove, M.P.M.; Bachmann, L.; Barson, M.; Bassirou, H.; Bitja Nyom, A.R.; Geraerts, M.; Hahn, C.; Huyse, T.; Kasembele, G.K.; Njom, S.; Resl, P.; Smeets, K.; Kmentová, N.</b> (2025). Adaptive evolution of stress response genes in parasites aligns with host niche diversity. <i>BMC Biology 23(1)</i>: 10. <a href=\"https://dx.doi.org/10.1186/s12915-024-02091-w\" target=\"_blank\">https://dx.doi.org/10.1186/s12915-024-02091-w</a>","BEntID":403866,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>BMC Biology 23(1)</i>: 10. <a href=\"https://dx.doi.org/10.1186/s12915-024-02091-w\" target=\"_blank\">https://dx.doi.org/10.1186/s12915-024-02091-w</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Cruz-Laufer, A.J.; Vanhove, M.P.M.; Bachmann, L.; Barson, M.; Bassirou, H.; Bitja Nyom, A.R.; Geraerts, M.; Hahn, C.; Huyse, T.; Kasembele, G.K.; Njom, S.; Resl, P.; Smeets, K.; Kmentová, N.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Cruz-Laufer, A.J. <i>et al.</i>","Englishabstract":"<h3>Background</h3>Stress responses are key the survival&nbsp;of parasites and, consequently, also the evolutionary success of these organisms. Despite this importance, our understanding of the evolution of molecular pathways dealing with environmental stressors in parasitic animals remains limited. Here, we tested the link between adaptive evolution of parasite stress response genes and their ecological diversity and species richness. We comparatively investigated antioxidant, heat shock, osmoregulatory, and behaviour-related genes (<i>foraging</i>) in two model parasitic flatworm lineages with contrasting ecological diversity, <i>Cichlidogyrus</i> and <i>Kapentagyrus</i> (Platyhelminthes: Monopisthocotyla), through whole-genome sequencing of 11 species followed by in silico exon bait capture as well as phylogenetic and codon analyses.<h3>Results</h3>We assembled the sequences of 48 stress-related genes and report the first <i>foraging</i> (<i>For</i>) gene orthologs in flatworms. We found duplications of heat shock (<i>Hsp</i>) and oxidative stress genes in <i>Cichlidogyrus</i> compared to <i>Kapentagyrus</i>. We also observed positive selection patterns in genes related to mitochondrial protein import (<i>Hsp</i>) and behaviour (<i>For</i>) in species of <i>Cichlidogyrus</i> infecting East African cichlids—a host lineage under adaptive radiation. These patterns are consistent with a potential adaptation linked to a co-radiation of these parasites and their hosts. Additionally, the absence of cytochrome P450 and kappa and sigma-class glutathione S-transferases in monogenean flatworms is reported, genes considered essential for metazoan life.<h3>Conclusions</h3>This study potentially identifies the first molecular function linked to a flatworm radiation. Furthermore, the observed gene duplications and positive selection indicate the potentially important role of stress responses for the ecological adaptation of parasite species.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Adaptive evolution of stress response genes in parasites aligns with host niche diversity","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-03-19 01:34:03.547940","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Comparative genomics, Positive selection, Heat shock proteins, Oxidative stress","OtherDescriptors":null,"Notes":null,"AnaPub":2025,"MonPub":null,"DateUpdate":"2025-03-12","DateCreate":"2025-03-12","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:001395404900003","VABBcode":null,"OpenAcc":1,"DOI":"10.1186/s12915-024-02091-w"},"refs":null,"anarec":{"AnaID":406068,"PubliDate":2025,"Pagination":"10","XtraPublOfAnaID":null,"ISBN":null,"Volume":"23","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":198526,"SerRR":"BMC Biology. 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