{"refrec":{"BRefID":409627,"RR":"<b>Roncalli, V.; Ascione, D.; Lauritano, C.; Carotenuto, Y.</b> (2025). The chemical defensome: A survey of environmental sensing and response genes in copepods. <i>International Journal of Molecular Sciences 26(4)</i>: 1546. <a href=\"https://dx.doi.org/10.3390/ijms26041546\" target=\"_blank\">https://dx.doi.org/10.3390/ijms26041546</a>","BEntID":407432,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>International Journal of Molecular Sciences 26(4)</i>: 1546. <a href=\"https://dx.doi.org/10.3390/ijms26041546\" target=\"_blank\">https://dx.doi.org/10.3390/ijms26041546</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Roncalli, V.; Ascione, D.; Lauritano, C.; Carotenuto, Y.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Roncalli, V. <i>et al.</i>","Englishabstract":"Highly conserved among eukaryotes, the chemical defensome protects organisms against chemical stressors and helps to reestablish the altered homeostatic state. The defensome includes genes such as transporters (e.g., <i>adenosine triphosphate ATP-binding cassette</i>), phase I and phase II detoxification enzymes, and antioxidant enzymes. During their life cycle, planktonic copepods, the most abundant and ubiquitous metazoans on Earth, are exposed to many environmental stressors that impair their survival and fitness. Here, using high-quality publicly available transcriptomic data, defensome genes were searched in copepods belonging to different orders and living in different environments (e.g., Antarctic, Subarctic, Mediterranean). Gene expression responses were investigated in four calanoids exposed to different stresses to identify a common and species-specific detoxification system. Our results confirm that the defensome is highly conserved among copepods but also report differences in the relative contribution of genes among species living in different habitats, suggesting a fitness adaptation to environmental pressures. The genes provided here can be used as biomarkers of chemical defense and can also be tested in other planktonic organisms to assess the “health” of marine organisms, which is useful for understanding environmental adaptations and they can be used to assess changes and make predictions at the population and community levels.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"The chemical defensome: A survey of environmental sensing and response genes in copepods","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-07-14 01:35:20.323916","timezone_type":1,"timezone":"+02:00"},"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2025,"MonPub":null,"DateUpdate":"2025-07-07","DateCreate":"2025-07-07","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1,"DOI":"10.3390/ijms26041546"},"refs":null,"anarec":{"AnaID":409627,"PubliDate":2025,"Pagination":"1546","XtraPublOfAnaID":null,"ISBN":null,"Volume":"26","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":270393,"SerRR":"International Journal of Molecular Sciences. 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