{"refrec":{"BRefID":409777,"RR":"<b>Sedeek, A.M.; Elfeky, H.; Hanora, A.S.; Solyman, S.M.</b> (2025). Genomic insights into biosynthesis and adaptation in the bioactive marine bacterium <i>Streptomyces albidoflavus</i> VIP-1 from the Red Sea. <i>BMC Microbiol. 25(1)</i>: 1-21. <a href=\"https://dx.doi.org/10.1186/s12866-025-04109-x\" target=\"_blank\">https://dx.doi.org/10.1186/s12866-025-04109-x</a>","BEntID":407582,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>BMC Microbiol. 25(1)</i>: 1-21. <a href=\"https://dx.doi.org/10.1186/s12866-025-04109-x\" target=\"_blank\">https://dx.doi.org/10.1186/s12866-025-04109-x</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Sedeek, A.M.; Elfeky, H.; Hanora, A.S.; Solyman, S.M.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Sedeek, A.M. <i>et al.</i>","Englishabstract":"<h3>Background</h3>Marine actinobacteria represent a diverse and biotechnologically rich group of microorganisms that have adapted to the unique challenges of marine ecosystems, including fluctuating salinities, temperatures, pressures, and nutrient levels. These environmental pressures have enhanced their biosynthetic capabilities, making them a prolific source of novel bioactive compounds.<h3>Results</h3>In this research, we report the isolation of a novel marine bacterium “<i>Streptomyces albidoflavus</i> VIP-1” associated with the marine invertebrate <i>Molgula citrine</i> isolated from the Red Sea. The secondary metabolites from the isolated strain exhibited significant in vitro antimicrobial and antitumor activities. The isolate has an estimated genome length of 7,090,100 base pairs. Based on the phylogenomic analysis and the values of digital DNA-DNA hybridization, average amino acids identity, and average nucleotide identity in comparison to genomes of known type strains, the isolated strain was found to belong to the species of <i>Streptomyces albidoflavus</i>. The genome of <i>S. albidoflavus</i> VIP-1 revealed genetic adaptations enabling its survival in harsh environments, including stress response genes and regulatory systems. Moreover, a wide variety of biosynthetic gene clusters belonging to polyketides, terpenes, and non-ribosomal peptides were detected. Finally, a comparative genome analysis with related marine and terrestrial strains highlighted its elevated biosynthetic potential.<h3>Conclusions</h3>The genome of <i>S. albidoflavus</i> VIP-1 reflects its potential as a valuable resource for biotechnological and biomedical applications. It reveals genetic adaptation to the marine environment through various anti-stress mechanisms and competitive strategies, including the production of antimicrobial metabolites.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Genomic insights into biosynthesis and adaptation in the bioactive marine bacterium <i>Streptomyces albidoflavus</i> VIP-1 from the Red Sea","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-07-25 01:58:07.936607","timezone_type":1,"timezone":"+02:00"},"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2025,"MonPub":null,"DateUpdate":"2025-07-09","DateCreate":"2025-07-09","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1,"DOI":"10.1186/s12866-025-04109-x"},"refs":null,"anarec":{"AnaID":409777,"PubliDate":2025,"Pagination":"1-21","XtraPublOfAnaID":null,"ISBN":null,"Volume":"25","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":212867,"SerRR":"BMC Microbiology. 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