{"refrec":{"BRefID":410252,"RR":"<b>Yuin, C.S.; Naidu, R.; Othman, I.; Zainal Abidin, S.A.</b> (2025). Consolidation of venom proteomes from major Cnidarian species (Scyphozoa and Cubozoa) obtained using liquid chromatography-tandem mass spectrometry. <i>Toxicon 265</i>: 108491. <a href=\"https://dx.doi.org/10.1016/j.toxicon.2025.108491\" target=\"_blank\">https://dx.doi.org/10.1016/j.toxicon.2025.108491</a>","BEntID":408061,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>Toxicon 265</i>: 108491. <a href=\"https://dx.doi.org/10.1016/j.toxicon.2025.108491\" target=\"_blank\">https://dx.doi.org/10.1016/j.toxicon.2025.108491</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Yuin, C.S.; Naidu, R.; Othman, I.; Zainal Abidin, S.A.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Yuin, C.S. <i>et al.</i>","Englishabstract":"Jellyfish envenomation is a significant cause of marine injuries and fatalities. Species under Scyphozoa and Cubozoa can trigger life-threatening effects upon envenomation. Despite the severity of these incidents, treatment options remain very limited. Proteomic information obtained using LC-MS/MS is crucial for identifying key toxins and elucidating the mechanisms underlying jellyfish envenomation. This review aims to provide a comprehensive list of venom proteomes from major Scyphozoans and Cubozoans. Among the ten major Scyphozoans and Cubozoans discussed in this review, the major toxin families were found to be phospholipases, proteases, metalloproteinases, serine protease inhibitors, pore-forming toxins, ion channel inhibitors, C-type lectins, and venom allergens. In addition to the relatively well-characterised venom toxins, several putative toxins were also identified. Interestingly, CfTX-like toxins, categorised as pore-forming toxins, were also homologous across most Scyphozoans apart from Cubozoans. These venom proteins are vital for developing antivenoms against various venomous jellyfish.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Consolidation of venom proteomes from major Cnidarian species (Scyphozoa and Cubozoa) obtained using liquid chromatography-tandem mass spectrometry","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-08-07 01:34:44.814756","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2025,"MonPub":null,"DateUpdate":"2025-07-31","DateCreate":"2025-07-31","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":1,"DOI":"10.1016/j.toxicon.2025.108491"},"refs":null,"anarec":{"AnaID":410252,"PubliDate":2025,"Pagination":"108491","XtraPublOfAnaID":null,"ISBN":null,"Volume":"265","Issue":null,"BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43961,"SerRR":"Toxicon. Elsevier: Oxford.  ISSN 0041-0101; e-ISSN 1879-3150","StandardTitleSer":"Toxicon","ISSN":"0041-0101","AbbrevSer":"Toxicon","StandardTitleMon":null,"StartPage":null,"Pages":null,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":null,"othpubs":null,"ownerships":null,"authors":[{"AutName":"Yuin","Firstname":"Chong Shi","Initials":"C.S.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":408061,"AutID":593925,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Naidu","Firstname":"Rakesh","Initials":"R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":408061,"AutID":593926,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Othman","Firstname":"Iekhsan","Initials":"I.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":408061,"AutID":593927,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Zainal Abidin","Firstname":"Syafiq Asnawi","Initials":"S.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":408061,"AutID":593928,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":415717,"LibID":36,"BRefID":410252,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"415717","RFID":null,"PaidValue":null,"Medium":"Server","Description":"VLIZ Open Access","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Open access","URL":null,"ClassifID":53,"Classification":"Open access","ReqLink":null,"ClassifTypID":1,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":null,"InternalReq":0,"LoggedInReq":0,"Disclaimer":null,"DutchDisclaimer":null,"FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":null,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Elsevier","City":"Oxford"}],"MONpubls":null,"pictures":[],"thestermsPath":null,"thestermsASFA":null,"taxtermsASFA":null,"geotermsASFA":null,"collections":[{"Collection":"VLIZ Acknowledged Publications","ShortName":"VLIZ ackn"}],"conf":null,"proj":null,"Physdatasets":null,"spcols":{"941":{"SpName":"LifeWatch Species Information Backbone","SpColID":941,"ParSpColID":39,"TopParID":39,"ShortName":"LifeWatch Species Information Backbone","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone"},"39":{"SpName":"VLIZ Acknowledged Publications","SpColID":39,"ParSpColID":null,"TopParID":null,"ShortName":"VLIZ ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"VLIZ ackn"},"507":{"SpName":"World Register of Marine Species","SpColID":507,"ParSpColID":null,"TopParID":null,"ShortName":"WoRMS website","URLLocation":null,"LibID":null,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":null,"SpColPath":"WoRMS website"},"915":{"SpName":"World Register of Marine Species (WoRMS) acknowledged","SpColID":915,"ParSpColID":941,"TopParID":39,"ShortName":"WoRMS ackn","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone/WoRMS ackn"},"947":{"SpName":"WoRMS ackn - direct reference","SpColID":947,"ParSpColID":915,"TopParID":39,"ShortName":"WoRMS ackn - direct","URLLocation":null,"LibID":36,"OpenRepoFlag":null,"SpTypID":null,"TopParIDNotWebsite":39,"SpColPath":"VLIZ ackn/LifeWatch Species Information Backbone/WoRMS ackn/WoRMS ackn - direct"}},"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":408061,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":408061,"AbstractFlag":1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1016/j.toxicon.2025.108491","externalID":"10.1016/j.toxicon.2025.108491","URLTypeCode":"DOI","URLID":148389,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":null,"taxterms":null,"geoterms":null,"othterms":null,"asfacodes":null,"asfa2codes":null,"thestermsFRIS":null,"taxtermsFRIS":null,"geotermsFRIS":null,"othtermsFRIS":null,"resmessage":"","complete":1,"sessions":{"newSesName":"Deckmyn, Anna, A.","newSesDate":{"date":"2025-07-31 08:37:31.457000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Deckmyn, Anna, A.","updSesDate":{"date":"2025-07-31 08:37:31.457000","timezone_type":3,"timezone":"Europe/Brussels"}}}