{"refrec":{"BRefID":411072,"RR":"<b>Vargas-Chávez, C.; Benítez-Álvarez, L.; Martínez-Redondo, G.I.; Álvarez-González, L.; Salces-Ortiz, J.; Eleftheriadi, K.; Escudero, N.; Guiglielmoni, N.; Flot, J.-F.; Novo, M.; Ruiz-Herrera, A.; McLysaght, A.; Fernández, R.</b> (2025). An episodic burst of massive genomic rearrangements and the origin of non-marine annelids. <i>Nature Ecology & Evolution 9(7)</i>: 1263-1279. <a href=\"https://dx.doi.org/10.1038/s41559-025-02728-1\" target=\"_blank\">https://dx.doi.org/10.1038/s41559-025-02728-1</a>","BEntID":408881,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Nature Ecology & Evolution 9(7)</i>: 1263-1279. <a href=\"https://dx.doi.org/10.1038/s41559-025-02728-1\" target=\"_blank\">https://dx.doi.org/10.1038/s41559-025-02728-1</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Vargas-Chávez, C.; Benítez-Álvarez, L.; Martínez-Redondo, G.I.; Álvarez-González, L.; Salces-Ortiz, J.; Eleftheriadi, K.; Escudero, N.; Guiglielmoni, N.; Flot, J.-F.; Novo, M.; Ruiz-Herrera, A.; McLysaght, A.; Fernández, R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Vargas-Chávez, C. <i>et al.</i>","Englishabstract":"The genomic basis of cladogenesis and adaptive evolutionary change has intrigued biologists for decades. Here we show that the tectonics of genome evolution in clitellates, a clade composed of most freshwater and all terrestrial species of the phylum Annelida, is characterized by extensive genome-wide scrambling that resulted in a massive loss of macrosynteny between marine annelids and clitellates. These massive rearrangements included the formation of putative neocentromeres with newly acquired transposable elements and preceded a further period of genome-wide reshaping events, potentially triggered by the loss of genes involved in genome stability and homoeostasis of cell division. Notably, whereas these rearrangements broke short-range interactions observed between <i>Hox</i> genes in marine annelids, they were reformed as long-range interactions in clitellates. Our findings reveal extensive genomic reshaping in clitellates at both the linear (2D) and three-dimensional (3D) levels, suggesting that unlike in other animal lineages where synteny conservation constrains structural evolution, clitellates exhibit a remarkable tolerance for chromosomal rearrangements. Our study thus suggests that the genomic landscape of Clitellata resulted from a rare burst of genomic changes that ended a long period of stability that persists across large phylogenetic distances","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"An episodic burst of massive genomic rearrangements and the origin of non-marine annelids","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2025-08-12 01:34:12.068406","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":null,"OtherDescriptors":null,"Notes":null,"AnaPub":2025,"MonPub":null,"DateUpdate":"2025-08-05","DateCreate":"2025-08-05","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":null,"VABBcode":null,"OpenAcc":0,"DOI":"10.1038/s41559-025-02728-1"},"refs":null,"anarec":{"AnaID":411072,"PubliDate":2025,"Pagination":"1263-1279","XtraPublOfAnaID":null,"ISBN":null,"Volume":"9","Issue":"7","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":282823,"SerRR":"Nature Ecology & Evolution. 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