{"refrec":{"BRefID":435549,"RR":"<b>Vindas, M.A.; Folkedal, O.; Aerts, J.; Øverli, Ø.; Nilsson, J.; Johansen, I.B.; Kristiansen, T.S.; Höglund, E.</b> (2025). Chronic stress and the development of a depression-like neuroendocrine profile in Atlantic salmon. <i>J. Exp. Biol. 228(11)</i>: jeb249862. <a href=\"https://dx.doi.org/10.1242/jeb.249862\" target=\"_blank\">https://dx.doi.org/10.1242/jeb.249862</a>","BEntID":433379,"PublicFlag":1,"CheckedFlag":0,"wosflag":1,"vabbflag":1,"RefStringPartII":". <i>J. Exp. Biol. 228(11)</i>: jeb249862. <a href=\"https://dx.doi.org/10.1242/jeb.249862\" target=\"_blank\">https://dx.doi.org/10.1242/jeb.249862</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Vindas, M.A.; Folkedal, O.; Aerts, J.; Øverli, Ø.; Nilsson, J.; Johansen, I.B.; Kristiansen, T.S.; Höglund, E.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Vindas, M.A. <i>et al.</i>","Englishabstract":"A subpopulation of aquaculture salmon are characterized by abnormal swimming behavior, growth stunting and anorexia, as well as chronically elevated cortisol and brain serotonergic levels. This profile is associated with a depression-like state (DLS) and these fish are unable to respond to further stressors. Whereas the underlying causes behind this phenomenon remain elusive, the physiological profile strongly suggests that chronic stress plays a significant role in this phenomenon. We subjected Atlantic salmon to a chronic stress regime consisting of incremental increases in environmental CO<sub>2</sub> concentrations during the freshwater phase for 68 days. Plasma corticosteroids, brain stem, hypothalamic and telencephalic serotonin concentrations and telencephalic whole transcriptome expression were then assessed under basal and acute stress conditions. We found that fish exposed to increased CO<sub>2</sub> were characterized by a long-term increase in cortisol, cortisol+cortisone and serotonin (5-HT) signaling in the brain stem. Furthermore, in response to an acute confinement stressor, the CO<sub>2</sub>-treated fish increased their levels of cortisol and cortisol+cortisone, and decreased their cortisone/cortisol ratio. But unlike the control fish, they were unable to also respond to confinement by increased 5-HT signaling in the brain stem. In terms of their transcriptional response, post-stress gene regulation in CO<sub>2</sub>-treated fish was the opposite of that observed in control fish. We believe this profile is an example of allostatic overload, characterized by the inability to cope with stress. This profile is associated with DLS, suggesting that chronic stress may be an important factor leading to the development of the DLS phenotype in salmon.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Chronic stress and the development of a depression-like neuroendocrine profile in Atlantic salmon","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-22 01:32:45.046060","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Allostatic overload, Serotonin, Cortisol, Cortisone, Whole transcriptome, CO2","OtherDescriptors":null,"Notes":null,"AnaPub":2025,"MonPub":null,"DateUpdate":"2025-10-21","DateCreate":"2025-10-21","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:001519604600023","VABBcode":null,"OpenAcc":0,"DOI":"10.1242/jeb.249862"},"refs":null,"anarec":{"AnaID":435549,"PubliDate":2025,"Pagination":"jeb249862","XtraPublOfAnaID":null,"ISBN":null,"Volume":"228","Issue":"11","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":43227,"SerRR":"The Journal of Experimental Biology. 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