{"refrec":{"BRefID":58371,"RR":"<b>Barata, C.; Solayan, A.; Porte, C.</b> (2004). Role of B-esterases in assessing toxicity of organophosphorus (chlorpyrifos, malathion) and carbamate (carbofuran) pesticides to <i>Daphnia magna</i>. <i>Aquat. Toxicol. 66(2)</i>: 125-139. <a href=\"http://dx.doi.org/10.1016/j.aquatox.2003.07.004\" target=\"_blank\">http://dx.doi.org/10.1016/j.aquatox.2003.07.004</a>","BEntID":55971,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Aquat. Toxicol. 66(2)</i>: 125-139. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2003.07.004\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2003.07.004</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Barata, C.; Solayan, A.; Porte, C.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Barata, C. <i>et al.</i>","Englishabstract":"In this study, the cladoceran <i>Daphnia magna</i> was exposed to two model organophosphorous and one carbamate pesticides including malathion, chlorpyrifos and carbofuran to assess acetylcholinesterase (AChE) and carboxylesterase (CbE) inhibition and recovery patterns and relate those responses with individual level effects. Our results revealed differences in enzyme inhibition and recovery patterns among the studied esterase enzymes and pesticides. CbE was more sensitive to organophosphorous than AChE, whereas both CbE and AChE showed equivalent sensitivities to the carbamate carbofuran. Recovery patterns of AChE and CbE activities following exposure to the studied pesticides were similar with 80-100% recoveries taking place 12 and 96 h after exposure to organophosphorous and carbamates pesticides, respectively. The physiological role of AChE and CbE inhibition patterns in <i>Daphnia</i> was examined by using organophosphorous and carbamate compounds alone and with specific inhibitors of CbE. Under exposure to organophosphorous pesticides, survival of <i>Daphnia</i> juveniles was impaired at AChE inhibition levels higher than 50% whereas under exposure to the carbamate carbofuran low levels of AChE inhibition affected mortality. Inhibition of CbE by 80-90% increased toxicity to organophosphorous and carbamate pesticides by up to two- and four-fold, respectively. Our results suggest that both AChE and CbE enzymes are involved in determining toxicity of Daphnia to the studied chemicals and that AChE inhibition levels higher than 50% can be considered of environmental concern to <i>Daphnia</i> species.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Role of B-esterases in assessing toxicity of organophosphorus (chlorpyrifos, malathion) and carbamate (carbofuran) pesticides to <i>Daphnia magna</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Daphnia; chlorpyrifos; malathion; carbofuran; acetylcholinesterase;carboxylesterase","OtherDescriptors":"Daphnia; Chlorpyrifos; Malathion; Carbofuran; Acetylcholinesterase; Carboxylesterase","Notes":null,"AnaPub":2004,"MonPub":null,"DateUpdate":"2018-05-17","DateCreate":"2004-03-11","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000220007000002","VABBcode":null,"OpenAcc":1,"DOI":"10.1016/j.aquatox.2003.07.004"},"refs":null,"anarec":{"AnaID":58371,"PubliDate":2004,"Pagination":"125-139","XtraPublOfAnaID":null,"ISBN":null,"Volume":"66","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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