{"refrec":{"BRefID":59722,"RR":"<b>Verslycke, T.; Poelmans, S.; De Wasch, K.; De Brabander, H.; Janssen, C.R.<\/b> (2004). Testosterone and energy metabolism in the estuarine mysid <i>Neomysis integer<\/i> (Crustacea: Mysidacea) following exposure to endocrine disruptors. <i>Environ. Toxicol. Chem. 23(5)<\/i>: 1289-1296. <a href=\"http:\/\/dx.doi.org\/10.1897\/03-338\" target=\"_blank\">http:\/\/dx.doi.org\/10.1897\/03-338<\/a>","BEntID":57329,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Environ. Toxicol. Chem. 23(5)<\/i>: 1289-1296. <a href=\"http:\/\/dx.doi.org\/10.1897\/03-338\" target=\"_blank\">http:\/\/dx.doi.org\/10.1897\/03-338<\/a>","DocTypID":8,"DocType":"Journal article","MarineFlag":0,"FreshFlag":0,"BrackishFlag":1,"TerrestrialFlag":0,"Authorstring":"Verslycke, T.; Poelmans, S.; De Wasch, K.; De Brabander, H.; Janssen, C.R.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Verslycke, T. <i>et al.<\/i>","Englishabstract":"A diverse set of reference compounds suspected of having an endocrine-disrupting mode of action (i.e., testosterone, flutamide, ethinylestradiol, precocene, nonylphenol, fenoxycarb, and methoprene) were tested for acute toxicity to the estuarine mysid <em>Neomysis integer<\/em> (Crustacea: Mysidacea). <em>Neomysis integer<\/em> was very sensitive to all tested compounds, with 96-h median lethal concentrations in a narrow range between 0.32 and 1.95 mg\/L. The pesticides methoprene and fenoxycarb, both synthetic insect juvenile hormone analogs, were most toxic to <em>N. integer.<\/em> In addition, the short-term sublethal effects of methoprene and nonylphenol (an estrogen agonist) on the energy and steroid metabolism of <em>N. integer<\/em> were evaluated. Both compounds significantly affected energy and testosterone metabolism of <em>N. integer<\/em> at concentrations below acute toxicity levels. Energy consumption in methoprene- and nonylphenol-exposed mysids was significantly induced at 100 \u00b5g\/L, resulting in a lower cellular energy allocation in these animals. Testosterone phase I metabolism was affected at 10 \u00b5g\/L, whereas glycosylation was the most important phase II pathway affected in mysids exposed to 100 \u00b5g\/L of both compounds. Methoprene exposure resulted in a concentration-dependent increase in the metabolic androgenization ratio. Mysids exposed to nonylphenol at 10 \u00b5g\/L had a significantly higher metabolic androgenization ratio. The present study indicates that energy and testosterone metabolism of mysids, as endpoints, are able to detect endocrine-disruptive activity of chemicals after short-term exposure to environmentally realistic levels of endocrine disruptors.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Testosterone and energy metabolism in the estuarine mysid <i>Neomysis integer<\/i> (Crustacea: Mysidacea) following exposure to endocrine disruptors","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-16 01:31:26.649100","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Testosterone metabolism; Endocrine disruption","OtherDescriptors":null,"Notes":null,"AnaPub":2004,"MonPub":null,"DateUpdate":"2014-10-09","DateCreate":"2004-04-27","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000221432400025","VABBcode":null,"OpenAcc":0,"DOI":"10.1897\/03-338"},"refs":null,"anarec":{"AnaID":59722,"PubliDate":2004,"Pagination":"1289-1296","XtraPublOfAnaID":null,"ISBN":null,"Volume":"23","Issue":"5","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42839,"SerRR":"Environmental Toxicology and Chemistry. Setac Press: New York.  ISSN 0730-7268; e-ISSN 1552-8618","StandardTitleSer":"Environmental Toxicology and Chemistry","ISSN":"0730-7268","AbbrevSer":"Environ. Toxicol. 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