{"refrec":{"BRefID":61488,"RR":"Mottaleb, M.A.; Zhao, X.; Curtis, L.R.; Sovocool, G.W. (2004). Formation of nitro musk adducts of rainbow trout hemoglobin for potential use as biomarkers of exposure. Aquat. Toxicol. 67(4): 315-324. https://dx.doi.org/10.1016/j.aquatox.2004.01.004","BEntID":58125,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". Aquat. Toxicol. 67(4): 315-324. https://dx.doi.org/10.1016/j.aquatox.2004.01.004","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":1,"BrackishFlag":1,"TerrestrialFlag":0,"Authorstring":"Mottaleb, M.A.; Zhao, X.; Curtis, L.R.; Sovocool, G.W.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Mottaleb, M.A. et al.","Englishabstract":"The high use of nitro musk xylene (MX) and musk ketone (MK) as fragrances, and their persistence and bioaccumulation potential make them ubiquitous environmental contaminants. The 4-amino-MX (AMX) and 2-amino-MK (AMK) metabolites have been detected in trout fish hemoglobin (Hb) samples by gas chromatography-ion trap-mass spectrometry (GC-MS). Twelve Hb samples prepared from rainbow trout that were exposed to MX and MK, over a period of 24 and 72 h, were analyzed. Amino metabolites were liberated by basic hydrolysis and extracted from the fish Hb into n-hexane. The extract was concentrated, analyzed, and spiked with a standard solution (80 pg/µl) of AMX or AMK and reanalyzed. Concentrations of AMX from 10 to 25 ng/g were detected in Hb from fish taken 24 and 72 h after MX exposure. At 24 and 72 h after MK exposure, the concentration of AMK was found to be 25-51 ng/g and 9.5-25 ng/g, respectively. Concentrations of AMK in Hb from two of the three trout were substantially lower after 72 h compared with 24 h exposure. The AMX and AMK metabolites were not detected in four control samples. Average recoveries exceeding 89 and 86% could be achieved for AMX and AMK, respectively, with a coefficient of variation (CV) around 5%.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Formation of nitro musk adducts of rainbow trout hemoglobin for potential use as biomarkers of exposure","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-04-26 01:31:10.792214","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"biomarkers; nitro musk; Hb adducts; fish","OtherDescriptors":"Biomarkers; Nitro musk; Hb adducts; Fish","Notes":null,"AnaPub":2004,"MonPub":null,"DateUpdate":"2020-09-16","DateCreate":"2004-05-14","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000221137500002","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2004.01.004"},"refs":null,"anarec":{"AnaID":61488,"PubliDate":2004,"Pagination":"315-324","XtraPublOfAnaID":null,"ISBN":null,"Volume":"67","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam. ISSN 0166-445X; e-ISSN 1879-1514","StandardTitleSer":"Aquatic Toxicology","ISSN":"0166-445X","AbbrevSer":"Aquat. Toxicol.","StandardTitleMon":null,"StartPage":315,"Pages":10,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":{"Line1":"P.O. Box 93478, Las Vegas","Email":"mottaleb@mohammad@epa.gov","Line2":null,"EnvName":"USA"},"othpubs":null,"ownerships":null,"authors":[{"AutName":"Mottaleb","Firstname":null,"Initials":"M.A.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58125,"AutID":45370,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Zhao","Firstname":"Xianyong","Initials":"X.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58125,"AutID":37892,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Curtis","Firstname":null,"Initials":"L.R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58125,"AutID":3078,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Sovocool","Firstname":null,"Initials":"G.W.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58125,"AutID":45371,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":351172,"LibID":36,"BRefID":61488,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":null,"ShelfLocCode":"351172","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"
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