{"refrec":{"BRefID":61489,"RR":"<b>Shaw, J.P.; Large, A.T.; Donkin, P.; Evans, S.V.; Staff, F.J.; Livingstone, D.R.; Chipman, J.K.; Peter, L.D.</b> (2004). Seasonal variation in cytochrome P450 immunopositive protein levels, lipid peroxidation and genetic toxicity in digestive gland of the mussel <i>Mytilus edulis</i>. <i>Aquat. Toxicol. 67(4)</i>: 325-336. <a href=\"http://dx.doi.org/10.1016/j.aquatox.2004.01.013\" target=\"_blank\">http://dx.doi.org/10.1016/j.aquatox.2004.01.013</a>","BEntID":58126,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":null,"RefStringPartII":". <i>Aquat. Toxicol. 67(4)</i>: 325-336. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2004.01.013\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2004.01.013</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Shaw, J.P.; Large, A.T.; Donkin, P.; Evans, S.V.; Staff, F.J.; Livingstone, D.R.; Chipman, J.K.; Peter, L.D.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Shaw, J.P. <i>et al.</i>","Englishabstract":"The relationship between cytochrome P450 1A- and 2E-immunopositive proteins, lipid peroxidation and DNA strand breaks (SBs) was studied in <i>Mytilus edulis</i> digestive gland at different seasons and at different sites around the UK coast. Cytochrome P4501A (CYP1A)-immunopositive protein and DNA strand breaks were generally lowest in December but there was no correlation between PAH exposure (indicated by chemical measurement and CYP1A-immunopositive protein expression) and DNA strand breaks which was highest at the relatively non-polluted site (Port Quin). As with CYP1A, CYP2E1-immunopositive protein was maximal at most sites in May. Lipid peroxidation, in contrast, did not alter markedly throughout the year. In conclusion, DNA strand breakage was not correlated with any of the above parameters although it did correlate with \"scope for growth\" as did the inverse of PAH levels. The study highlights the need to establish the relative contribution of DNA damage and DNA repair processes to the production of DNA strand breaks and emphasises the need to consider seasonal variation in interpretation of biomarkers.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Seasonal variation in cytochrome P450 immunopositive protein levels, lipid peroxidation and genetic toxicity in digestive gland of the mussel <i>Mytilus edulis</i>","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2024-12-10 01:33:17.368041","timezone_type":1,"timezone":"+01:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"Mytilus edulis; p450; lipid peroxidation; genotoxicity; comet assay;seasonality","OtherDescriptors":"Mytilus edulis; P450; Lipid peroxidation; Genotoxicity; Comet assay; Seasonality","Notes":null,"AnaPub":2004,"MonPub":null,"DateUpdate":"2018-05-17","DateCreate":"2004-05-14","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000221137500003","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2004.01.013"},"refs":null,"anarec":{"AnaID":61489,"PubliDate":2004,"Pagination":"325-336","XtraPublOfAnaID":null,"ISBN":null,"Volume":"67","Issue":"4","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. Elsevier Science: Tokyo; New York; London; Amsterdam.  ISSN 0166-445X; e-ISSN 1879-1514","StandardTitleSer":"Aquatic Toxicology","ISSN":"0166-445X","AbbrevSer":"Aquat. Toxicol.","StandardTitleMon":null,"StartPage":325,"Pages":12,"ToPubliDate":null,"BRefBibLvlCode":"S","SerNotes":null},"monrec":null,"serrec":null,"relations":null,"relationsRev":null,"addrec":{"Line1":"Prospect Place","Email":"jens@pml.ac.uk","Line2":null,"EnvName":"UK"},"othpubs":null,"ownerships":null,"authors":[{"AutName":"Shaw","Firstname":null,"Initials":"J.P.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58126,"AutID":45372,"OrderNr":1,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Large","Firstname":null,"Initials":"A.T.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58126,"AutID":45373,"OrderNr":2,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Donkin","Firstname":"Peter","Initials":"P.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58126,"AutID":13217,"OrderNr":3,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Evans","Firstname":null,"Initials":"S.V.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58126,"AutID":45374,"OrderNr":4,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Staff","Firstname":null,"Initials":"F.J.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58126,"AutID":45375,"OrderNr":5,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Livingstone","Firstname":"David","Initials":"D.R.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58126,"AutID":13218,"OrderNr":6,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Chipman","Firstname":null,"Initials":"J.K.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58126,"AutID":40397,"OrderNr":7,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null},{"AutName":"Peter","Firstname":null,"Initials":"L.D.","Affiliation":null,"Discriminator":null,"CorporateFlag":0,"BEntID":58126,"AutID":45376,"OrderNr":8,"DegrID":null,"EditorFlag":0,"CorrespFlag":0,"IllustratorFlag":0,"ReviserFlag":0,"TranslatorFlag":0,"InsAcronym":null,"InsFSN":null,"ORCID":null,"PersID":null,"InsID":null}],"mapdetails":null,"datasets":null,"monographs":null,"monparts":null,"serparts":null,"BEntOpen":null,"BEntPrivate":null,"availability":[{"BInstID":149847,"LibID":36,"BRefID":61489,"EmbargoDate":null,"FullEmbargoDate":null,"PhysMedID":16,"hasOCRd":1,"ShelfLocCode":"149847","RFID":null,"PaidValue":null,"Medium":"Server","Description":"Interne VLIZ documenten","Acronym":"VLIZ","Library":"Vlaams Instituut voor de Zee","DutchTerm":"Non-open access","URL":null,"ClassifID":228,"Classification":"Non-open access","ReqLink":1,"ClassifTypID":3,"URLLocation":"https://www.vliz.be/imisdocs/publications/","SubDir":1,"InternalReq":1,"LoggedInReq":1,"Disclaimer":"Disclaimer_VLIZ_Intern","DutchDisclaimer":"<p>Deze publicatie is enkel beschikbaar voor persoonlijk gebruik binnen de Innovocean site <br />en mag op geen enkele manier verder worden verspreid.</p>","FileFormat":".pdf","FileDescr":"pdf","InsPub":1,"InsID":36,"FileFormID":6,"LendableFlag":1,"PublicFlag":1,"orderLib":"A","Notes":null,"AccConID":null,"AccessConstraint":null,"LicURL":null}],"litstyles":null,"thespers":null,"arch2discl":null,"SERpubls":[{"PublName":"Elsevier Science","City":"Tokyo; New York; London; Amsterdam"}],"MONpubls":null,"pictures":[],"thestermsPath":[{"ThesaurusTerm":"Antioxidants","ThestID":461,"Acronym":"ASFA","ThesTermPath":"Agents > Antioxidants"},{"ThesaurusTerm":"Lipids","ThestID":4763,"Acronym":"ASFA","ThesTermPath":"Chemical compounds > Organic compounds > Lipids"},{"ThesaurusTerm":"Lipid peroxidation","ThestID":147959,"Acronym":"CAB","ThesTermPath":"Chemical reactions > Redox reactions > Chemical reactions > Oxidation > Peroxidation > Lipid peroxidation"},{"ThesaurusTerm":"Marine molluscs","ThestID":5010,"Acronym":"ASFA","ThesTermPath":"Fauna > Aquatic organisms > Aquatic animals > Shellfish > Marine organisms > Marine molluscs"},{"ThesaurusTerm":"Genotoxicity","ThestID":79950,"Acronym":"CSA","ThesTermPath":"Genotoxicity"},{"ThesaurusTerm":"Seasonality","ThestID":7330,"Acronym":"ASFA","ThesTermPath":"Periodicity > Seasonality"},{"ThesaurusTerm":"Genotoxicity","ThestID":140705,"Acronym":"CAB","ThesTermPath":"Toxicity > Genotoxicity"}],"thestermsASFA":[{"ThesaurusTerm":"Antioxidants"},{"ThesaurusTerm":"Genotoxicity"},{"ThesaurusTerm":"Genotoxicity"},{"ThesaurusTerm":"Lipid peroxidation"},{"ThesaurusTerm":"Lipids"},{"ThesaurusTerm":"Marine molluscs"},{"ThesaurusTerm":"Seasonality"}],"taxtermsASFA":[{"TaxTerm":"Mytilus edulis"}],"geotermsASFA":null,"collections":null,"conf":null,"proj":null,"Physdatasets":null,"spcols":null,"doi":null,"publs":null,"serparttypes":null,"monauthors":null,"MParts":null,"SParts":null,"hLibs":null,"langs":[{"BEntID":58126,"AbstractFlag":-1,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"},{"BEntID":58126,"AbstractFlag":0,"LangID":15,"LangCode":"en","Lang":"English","DutchTerm":"Engels","LangCodeExtended":"eng"}],"urls":[{"URL":"https://dx.doi.org/10.1016/j.aquatox.2004.01.013","externalID":"10.1016/j.aquatox.2004.01.013","URLTypeCode":"DOI","URLID":2557,"URLTypID":13,"URLType":"DOI","URLPrefix":"http://dx.doi.org/"}],"thesterms":[{"ThesaurusTerm":"Antioxidants","ThestID":461,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Genotoxicity","ThestID":79950,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"},{"ThesaurusTerm":"Genotoxicity","ThestID":140705,"Acronym":"CAB","ThesTypID":4,"ThesType":"CAB Thesaurus"},{"ThesaurusTerm":"Lipid peroxidation","ThestID":147959,"Acronym":"CAB","ThesTypID":4,"ThesType":"CAB Thesaurus"},{"ThesaurusTerm":"Lipids","ThestID":4763,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Marine molluscs","ThestID":5010,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Seasonality","ThestID":7330,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxterms":[{"TaxTerm":"Mytilus edulis","AphiaID":140480,"TaxtID":25121}],"geoterms":null,"othterms":[{"OtherTerm":"Comet assay","OthtID":2602},{"OtherTerm":"P450","OthtID":6632}],"asfacodes":null,"asfa2codes":null,"thestermsFRIS":[{"ThesaurusTerm":"Antioxidants","DutchTerm":"Anti-oxidanten","ThestID":461,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Genotoxicity","DutchTerm":null,"ThestID":79950,"Acronym":"CSA","ThesTypID":2,"ThesType":"CSA Technology Research Database Master Thesaurus"},{"ThesaurusTerm":"Genotoxicity","DutchTerm":null,"ThestID":140705,"Acronym":"CAB","ThesTypID":4,"ThesType":"CAB Thesaurus"},{"ThesaurusTerm":"Lipid peroxidation","DutchTerm":null,"ThestID":147959,"Acronym":"CAB","ThesTypID":4,"ThesType":"CAB Thesaurus"},{"ThesaurusTerm":"Lipids","DutchTerm":"Vetten","ThestID":4763,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Marine molluscs","DutchTerm":"Mariene weekdieren","ThestID":5010,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"},{"ThesaurusTerm":"Seasonality","DutchTerm":"seizoenaliteit","ThestID":7330,"Acronym":"ASFA","ThesTypID":1,"ThesType":"ASFA Thesaurus List"}],"taxtermsFRIS":[{"TaxTerm":"Mytilus edulis","DutchTerm":"Mossel","AphiaID":140480,"TaxtID":25121}],"geotermsFRIS":null,"othtermsFRIS":[{"OtherTerm":"Comet assay","DutchTerm":null,"OthtID":2602},{"OtherTerm":"P450","DutchTerm":null,"OthtID":6632}],"resmessage":"","complete":1,"sessions":{"newSesName":"Chisala, Chilekwa, C.","newSesDate":{"date":"2004-05-14 15:13:10.833000","timezone_type":3,"timezone":"Europe/Brussels"},"updSesName":"Lyssens, Liesbeth, L.","updSesDate":{"date":"2018-05-17 21:28:56.790000","timezone_type":3,"timezone":"Europe/Brussels"}}}