{"refrec":{"BRefID":68681,"RR":"<b>Mochida, K.; Ohkubo, N.; Matsubara, T.; Ito, K.; Kakuno, A.; Fujii, K.</b> (2004). Effects of endocrine-disrupting chemicals on expression of ubiquitin C-terminal hydrolase mRNA in testis and brain of the Japanese common goby. <i>Aquat. Toxicol. 70(2)</i>: 123-136. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2004.08.001\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2004.08.001</a>","BEntID":64874,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 70(2)</i>: 123-136. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2004.08.001\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2004.08.001</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Mochida, K.; Ohkubo, N.; Matsubara, T.; Ito, K.; Kakuno, A.; Fujii, K.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Mochida, K. <i>et al.</i>","Englishabstract":"We investigated the effects of endocrine-disrupting chemicals (EDCs) on the expression of ubiquitin C-terminal hydrolase (UCH) mRNA in the testis and brain of the Japanese common goby, <i>Acanthogobius flavimanus</i>. The cDNA sequence of goby UCH contained an open reading frame encoding 220 amino acid residues (M<sub>r</sub> = 24,223) with 51.3% overall sequence identity with human and mouse UCHL1. A competitive PCR assay was used to quantify the levels of UCH mRNA in the testis and brain of male gobies after exposure to bisphenol A, nonylphenol, or estradiol-17β for 3 weeks. Exposure to estradiol-17β at a nominal concentration of 100 ng/L induced significant increase in UCH mRNA levels in both testis and brain (P < 0.05), whereas exposure to nonylphenol induced a significant decrease in UCH mRNA levels in the testis (P < 0.01). These results suggest that EDCs can either positively or negatively regulate UCH mRNA levels.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Effects of endocrine-disrupting chemicals on expression of ubiquitin C-terminal hydrolase mRNA in testis and brain of the Japanese common goby","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-11 01:31:30.784286","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"estradiol-17 beta; nonylphenol; competitive PCP assay; spermatogenesis;teleost","OtherDescriptors":"Estradiol-17β; Nonylphenol; Competitive PCR assay; Spermatogenesis; Teleost","Notes":null,"AnaPub":2004,"MonPub":null,"DateUpdate":"2020-10-05","DateCreate":"2004-12-09","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000225203900003","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2004.08.001"},"refs":null,"anarec":{"AnaID":68681,"PubliDate":2004,"Pagination":"123-136","XtraPublOfAnaID":null,"ISBN":null,"Volume":"70","Issue":"2","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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