{"refrec":{"BRefID":70460,"RR":"<b>Desantis, S.; Corriero, A.; Cirillo, F.; Deflorio, M.; Brill, M.; Griffiths, M.; Lopata, A.L.; De La Serna, J.M.; Bridges, C.R.; Kime, D.E.; de Metrio, G.</b> (2005). Immunohistochemical localization of CYP1A, vitellogenin and Zona radiata proteins in the liver of swordfish (<i>Xiphias gladius</i> L.) taken from the Mediterranean Sea, South Atlantic, South Western Indian and Central North Pacific Oceans. <i>Aquat. Toxicol. 71(1)</i>: 1-12. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2004.10.005\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2004.10.005</a>","BEntID":66520,"PublicFlag":1,"CheckedFlag":1,"wosflag":1,"vabbflag":0,"RefStringPartII":". <i>Aquat. Toxicol. 71(1)</i>: 1-12. <a href=\"https://dx.doi.org/10.1016/j.aquatox.2004.10.005\" target=\"_blank\">https://dx.doi.org/10.1016/j.aquatox.2004.10.005</a>","DocTypID":8,"DocType":"Journal article","MarineFlag":1,"FreshFlag":0,"BrackishFlag":0,"TerrestrialFlag":0,"Authorstring":"Desantis, S.; Corriero, A.; Cirillo, F.; Deflorio, M.; Brill, M.; Griffiths, M.; Lopata, A.L.; De La Serna, J.M.; Bridges, C.R.; Kime, D.E.; de Metrio, G.","OrigTitleTranslFlag":0,"Authorstringtrunc":"Desantis, S. <i>et al.</i>","Englishabstract":"Cytochrome P4501A (CYP1A) monoxygenase, vitellogenin (Vtg) and Zona radiata proteins (Zrp) are frequently used as biomarkers of fish exposure to organic contaminants. In this work, swordfish liver sections obtained from the Mediterranean Sea, the South African coasts (South Atlantic and South Western Indian Oceans) and the Central North Pacific Ocean were immunostained with antisera against CYP1A, Zrp, and Vtg. CYP1A induction was found in hepatocytes, epithelium of the biliary ductus and the endothelium of large blood vessels of fish from the Mediterranean Sea and South African waters, but not from the Pacific Ocean. Zrp and Vtg were immunolocalized in hepatocytes of male swordfish from the Mediterranean Sea and from South African waters. Plasma Dot-Blot analysis, performed in Mediterranean and Pacific specimens, revealed the presence of Zrp and Vtg in males from Mediterranean but not from Pacific. These results confirm previous findings about the potential exposure of Mediterranean swordfish to endocrine, disrupting chemicals and raise questions concerning the possible presence of xenobiotic contaminants off the Southern coasts of South Africa in both the South Atlantic and South Western Indian Oceans.","AbstractOtherLang":null,"BibLvlCode":"AS","StandardTitle":"Immunohistochemical localization of CYP1A, vitellogenin and Zona radiata proteins in the liver of swordfish (<i>Xiphias gladius</i> L.) taken from the Mediterranean Sea, South Atlantic, South Western Indian and Central North Pacific Oceans","OrigTitleLangCode":"en","OrigTitleLangCodeExtended":"eng","OrigTitleLangID":15,"DateLastModified":{"date":"2026-06-09 01:31:13.202351","timezone_type":1,"timezone":"+02:00"},"UserAccessRight":null,"UserAccID":null,"AuthorKeywords":"swordfish liver; CYP1A; Zona radiata proteins; vitellogenin;immunochemistry; eadocrine disruption","OtherDescriptors":"Swordfish liver; CYP1A; Zona radiata proteins; Vitellogenin; Immunohistochemistry; Endocrine disruption","Notes":null,"AnaPub":2005,"MonPub":null,"DateUpdate":"2020-10-06","DateCreate":"2005-02-08","SecASFANote":null,"ConfID":null,"PeerRev":1,"VlizCoreFlag":1,"WoScode":"WOS:000226566400001","VABBcode":null,"OpenAcc":0,"DOI":"10.1016/j.aquatox.2004.10.005"},"refs":null,"anarec":{"AnaID":70460,"PubliDate":2005,"Pagination":"1-12","XtraPublOfAnaID":null,"ISBN":null,"Volume":"71","Issue":"1","BRefMon":null,"BRefMonRR":null,"BRefXtra":null,"BRefXtraRR":null,"SerBRefID":42203,"SerRR":"Aquatic Toxicology. 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